Histone H2A.V (H2A.F/Z) (H2A.Z variant histone 2)
1_MAGGK 6_ AGKDS 11_ GKAKA 16_ KAVSR 21_ SQRAG 26_ LQFPV 31_ GRIHR 36_ HLKTR 41_ TTSHG 46_ RVGAT 51_ AAVYS 56_ AAILE 61_ YLTAE 66_ VLELA 71_ GNASK 76_ DLKVK 81_ RITPR 86_ HLQLA 91_ IRGDE 96_ ELDSL 101_ IKATI 106_ AGGGV 111_ IPHIH 116_ KSLIG 121_KKGQQ
1: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)