E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai)
1_MDHTD 6_ NELQG 11_ TNSSG 16_ SLGGL 21_ DVRRR 26_ IPIKL 31_ ISKQA 36_ NKAKP 41_ APRTQ 46_ RTINR 51_ MPAKA 56_ PPGDE 61_ EGFDY 66_ NEEER 71_ YDCKG 76_ GELFA 81_ NQRRF 86_ PGHLF 91_ WDFQI 96_ NILGE 101_ KDDTP 106_ VHFCD 111_ KCGLP 116_ IKIYG 121_ RMIPC 126_ KHVFC 131_ YDCAI 136_ LHEKK 141_ GDKMC 146_ PGCSD 151_ PVQRI 156_ EQCTR 161_ GSLFM 166_ CSIVQ 171_ GCKRT 176_ YLSQR 181_ DLQAH 186_ INHRH 191_ MRAGK 196_ PVTRA 201_ SLENV 206_ HPPIA 211_ PPPTE 216_ IPERF 221_ IMPPD 226_ KHHMS 231_ HIPPK 236_ QHIMM 241_ PPPPL 246_ QHVPH 251_ EHYNQ 256_ PHEDI 261_ RAPPA 266_ ELSMA 271_ PPPPR 276_ SVSQE 281_ TFRIS 286_ TRKHS 291_ NLITV 296_ PIQDD 301_ SNSGA 306_ REPPP 311_ PAPAP 316_ AHHHP 321_ EYQGQ 326_ PVVSH 331_ PHHIM 336_ PPQQH 341_ YAPPP 346_ PPPPP 351_ ISHPM 356_ PHPPQ 361_ AAGTP 366_ HLVYS 371_ QAPPP 376_ PMTSA 381_ PPPIT 386_ PPPGH 391_ IIAQM 396_ PPYMN 401_ HPPPG 406_ PPPPQ 411_ HGGPP 416_ VTAPP 421_ PHHYN 426_ PNSLP 431_ QFTED 436_ QGTLS 441_ PPFTQ 446_ PGGMS 451_ PGIWP 456_ APRGP 461_ PPPPR 466_ LQGPP 471_ SQTPL 476_ PGPHH 481_ PDQTR 486_YRPYY
1: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755)