Integrator complex subunit 8 (Int8) (Protein kaonashi-1)
1_MSAEA 6_ ADREA 11_ ATSSR 16_ PCTPP 21_ QTCWF 26_ EFLLE 31_ ESLLE 36_ KHLRK 41_ PCPDP 46_ APVQL 51_ IVQFL 56_ EQASK 61_ PSVNE 66_ QNQVQ 71_ PPPDN 76_ KRNRI 81_ LKLLA 86_ LKVAA 91_ HLKWD 96_ LDILE 101_ KSLSV 106_ PVLNM 111_ LLNEL 116_ LCISK 121_ VPPGT 126_ KHVDM 131_ DLATL 136_ PPTTA 141_ MAVLL 146_ YNRWA 151_ IRTIV 156_ QSSFP 161_ VKQAK 166_ PGPPQ 171_ LSVMN 176_ QMQQE 181_ KELTE 186_ NILKV 191_ LKEQA 196_ ADSIL 201_ VLEAA 206_ LKLNK 211_ DLYVH 216_ TMRTL 221_ DLLAM 226_ EPGMV 231_ NGETE 236_ SSTAG 241_ LKVKT 246_ EEMQC 251_ QVCYD 256_ LGAAY 261_ FQQGS 266_ TNSAV 271_ YENAR 276_ EKFFR 281_ TKELI 286_ AEIGS 291_ LSLHC 296_ TIDEK 301_ RLAGY 306_ CQACD 311_ VLVPS 316_ SDSTS 321_ QQLTP 326_ YSQVH 331_ ICLRS 336_ GNYQE 341_ VIQIF 346_ IEDNL 351_ TLSLP 356_ VQFRQ 361_ SVLRE 366_ LFKKA 371_ QQGNE 376_ ALDEI 381_ CFKVC 386_ ACNTV 391_ RDILE 396_ GRTIS 401_ VQFNQ 406_ LFLRP 411_ NKEKI 416_ DFLLE 421_ VCSRS 426_ VNLEK 431_ ASESL 436_ KGNMA 441_ AFLKN 446_ VCLGL 451_ EDLQY 456_ VFMIS 461_ SHELF 466_ ITLLK 471_ DEERK 476_ LLVDQ 481_ MRKRS 486_ PRVNL 491_ CIKPV 496_ TSFYD 501_ IPASA 506_ SVNIG 511_ QLEHQ 516_ LILSV 521_ DPWRI 526_ RQILI 531_ ELHGM 536_ TSERQ 541_ FWTVS 546_ NKWEV 551_ PSVYS 556_ GVILG 561_ IKDNL 566_ TRDLV 571_ YILMA 576_ KGLHC 581_ STVKD 586_ FSHAK 591_ QLFAA 596_ CLELV 601_ TEFSP 606_ KLRQV 611_ MLNEM 616_ LLLDI 621_ HTHEA 626_ GTGQA 631_ GERPP 636_ SDLIS 641_ RVRGY 646_ LEMRL 651_ PDIPL 656_ RQVIA 661_ EECVA 666_ FMLNW 671_ RENEY 676_ LTLQV 681_ PAFLL 686_ QSNPY 691_ VKLGQ 696_ LLAAT 701_ CKELP 706_ GPKES 711_ RRTAK 716_ DLWEV 721_ VVQIC 726_ SVSSQ 731_ HKRGN 736_ DGRVS 741_ LIKQR 746_ ESTLG 751_ IMYRS 756_ ELLSF 761_ IKKLR 766_ EPLVL 771_ TIILS 776_ LFVKL 781_ HNVRE 786_ DIVND 791_ ITAEH 796_ ISIWP 801_ SSIPN 806_ LQSVD 811_ FEAVA 816_ ITVKE 821_ LVRYT 826_ LSINP 831_ NNHSW 836_ LIIQA 841_ DIYFA 846_ TNQYS 851_ AALHY 856_ YLQAG 861_ AVCSD 866_ FFNKA 871_ VPPDV 876_ YTDQV 881_ IKRMI 886_ KCCSL 891_ LNCHT 896_ QVAIL 901_ CQFLR 906_ EIDYK 911_ TAFKS 916_ LQEQN 921_ SHDAM 926_ DSYYD 931_ YIWDV 936_ TILEY 941_ LTYLH 946_ HKRGE 951_ TDKRQ 956_ IAIKA 961_ IGQTE 966_ LNASN 971_ PEEVL 976_ QLAAQ 981_ RRKKK 986_FLQAM
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:28542170, PubMed:33243860, PubMed:34004147, PubMed:37080207, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:34004147, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint (PubMed:32966759, PubMed:33243860, PubMed:34004147, PubMed:37080207)