Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)
1_MREKG 6_ RRKKG 11_ RTWAE 16_ AAKTV 21_ LEKYP 26_ NTPMS 31_ HKEIL 36_ QVIQR 41_ EGLKE 46_ IRSGT 51_ SPLAC 56_ LNAML 61_ HTNSR 66_ GEEGI 71_ FYKVP 76_ GRMGV 81_ YTLKK 86_ DVPDG 91_ VKELS 96_ EGSEE 101_ SSDGQ 106_ SDSQS 111_ SENSS 116_ SSSDG 121_ GSNKE 126_ GKKSR 131_ WKRKV 136_ SSSSP 141_ QSGCP 146_ SPTIP 151_ AGKVI 156_ SPSQK 161_ HSKKA 166_ LKQAL 171_ KQQQQ 176_ KKQQQ 181_ QCRPS 186_ ISISS 191_ NQHLS 196_ LKTVK 201_ AASDS 206_ VPAKP 211_ ATWEG 216_ KQSDG 221_ QTGSP 226_ QNSNS 231_ SFSSS 236_ VKVEN 241_ TLLGL 246_ GKKSF 251_ QRSER 256_ LHTRQ 261_ MKRTK 266_ CADID 271_ VETPD 276_ SILVN 281_ TNLRA 286_ LINKH 291_ TFSVL 296_ PGDCQ 301_ QRLLL 306_ LLPEV 311_ DRQVG 316_ PDGLM 321_ KLNGS 326_ ALNNE 331_ FFTSA 336_ AQGWK 341_ ERLSE 346_ GEFTP 351_ EMQVR 356_ IRQEI 361_ EKEKK 366_ VEPWK 371_ EQFFE 376_ SYYGQ 381_ SSGLS 386_ LEDSK 391_ KLTAS 396_ PSDPK 401_ VKKTP 406_ AEQPK 411_ SMPVS 416_ EASLI 421_ RIVPV 426_ VSQSE 431_ CKEEA 436_ LQMSS 441_ PGRKE 446_ ECESQ 451_ GEVQP 456_ NFSTS 461_ SEPLL 466_ SSALN 471_ THELS 476_ SILPI 481_ KCPKD 486_ EDLLE 491_ QKPVT 496_ SAEQE 501_ SEKNH 506_ LTTAS 511_ NYNKS 516_ ESQES 521_ LVTSP 526_ SKPKS 531_ PGVEK 536_ PIVKP 541_ TAGAG 546_ PQETN 551_ MKEPL 556_ ATLVD 561_ QSPES 566_ LKRKS 571_ SLTQE 576_ EAPVS 581_ WEKRP 586_ RVTEN 591_ RQHQQ 596_ PFQVS 601_ PQPFL 606_ NRGDR 611_ IQVRK 616_ VPPLK 621_ IPVSR 626_ ISPMP 631_ FHPSQ 636_ VSPRA 641_ RFPVS 646_ ITSPN 651_ RTGAR 656_ TLADI 661_ KAKAQ 666_ LVKAQ 671_ RAAAA 676_ AAAAA 681_ AAAAS 686_ VGGTI 691_ PGPGP 696_ GGGQG 701_ PGEGG 706_ EGQTA 711_ RGGSP 716_ GSDRV 721_ SETGK 726_ GPTLE 731_ LAGTG 736_ SRGGT 741_ RELLP 746_ CGPET 751_ QPQSE 756_ TKTTP 761_ SQAQP 766_ HSVSG 771_ AQLQQ 776_ TPPVP 781_ PTPAV 786_ SGACT 791_ SVPSP 796_ AHIEK 801_ LDNEK 806_ LNPTR 811_ ATATV 816_ ASVSH 821_ PQGPS 826_ SCRQE 831_ KAPSP 836_ TGPAL 841_ ISGAS 846_ PVHCA 851_ ADGTV 856_ ELKAG 861_ PSKNI 866_ PNPSA 871_ SSKTD 876_ ASVPV 881_ AVTPS 886_ PLTSL 891_ LTTAT 896_ LEKLP 901_ VPQVS 906_ ATTAP 911_ AGSAP 916_ PSSTL 921_ PAASS 926_ LKTPG 931_ TSLNM 936_ NGPTL 941_ RPTSS 946_ IPANN 951_ PLVTQ 956_ LLQGK 961_ DVPME 966_ QILPK 971_ PLTKV 976_ EMKTV 981_ PLTAK 986_ EERGM 991_ GALIA 996_ TNTTE 1001_ NSTRE 1006_ EVNER 1011_ QSHPA 1016_ TQQQL 1021_ GKTLQ 1026_ SKQLP 1031_ QVPRP 1036_ LQLFS 1041_ AKELR 1046_ DSSID 1051_ THQYH 1056_ EGLSK 1061_ ATQDQ 1066_ ILQTL 1071_ IQRVR 1076_ RQNLL 1081_ SVVPP 1086_ SQFNF 1091_ AHSGF 1096_ QLEDI 1101_ STSQR 1106_ FMLGF 1111_ AGRRT 1116_ SKPAM 1121_ AGHYL 1126_ LNIST 1131_ YGRGS 1136_ ESFRR 1141_ THSVN 1146_ PEDRF 1151_ CLSSP 1156_ TEALK 1161_ MGYTD 1166_ CKNAT 1171_ GESSS 1176_ SKEDD 1181_ TDEES 1186_ TGDEQ 1191_ ESVTV 1196_ KEEPQ 1201_ VSQSA 1206_ GKGDT 1211_ SSGPH 1216_ SRETL 1221_ STSDC 1226_ LASKN 1231_ VKAEI 1236_ PLNEQ 1241_ TTLSK 1246_ ENYLF 1251_ TRGQT 1256_ FDEKT 1261_ LARDL 1266_ IQAAQ 1271_ KQMAH 1276_ AVRGK 1281_ AIRSS 1286_ PELFS 1291_ STVLP 1296_ LPADS 1301_ PTHQP 1306_ LLLPP 1311_ LQTPK 1316_ LYGSP 1321_ TQIGP 1326_ SYRGM 1331_ INVST 1336_ SSDMD 1341_ HNSAV 1346_ PGSQV 1351_ SSNVG 1356_ DVMSF 1361_ SVTVT 1366_ TIPAS 1371_ QAMNP 1376_ SSHGQ 1381_ TIPVQ 1386_ AFSEE 1391_ NSIEG 1396_ TPSKC 1401_ YCRLK 1406_ AMIMC 1411_ KGCGA 1416_ FCHDD 1421_ CIGPS 1426_KLCVS
1: Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:30664650, PubMed:36180891). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (PubMed:30664650, PubMed:36180891). ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex (By similarity) (PubMed:30664650). The ASXL proteins are essential for chromatin recruitment and transcriptional activation of associated genes (By similarity). ASXL1 and ASXL2 are important for BAP1 protein stability (PubMed:30664650)