Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
1_MASAV 6_ RGSRP 11_ WPRLG 16_ LQLQF 21_ AALLL 26_ GTLSP 31_ QVHTL 36_ RPENL 41_ LLVST 46_ LDGSL 51_ HALSK 56_ QTGDL 61_ KWTLR 66_ DDPVI 71_ EGPMY 76_ VTEMA 81_ FLSDP 86_ ADGSL 91_ YILGT 96_ QKQQG 101_ LMKLP 106_ FTIPE 111_ LVHAS 116_ PCRSS 121_ DGVFY 126_ TGRKQ 131_ DAWFV 136_ VDPES 141_ GETQM 146_ TLTTE 151_ GPSTP 156_ RLYIG 161_ RTQYT 166_ VTMHD 171_ PRAPA 176_ LRWNT 181_ TYRRY 186_ SAPPM 191_ DGSPG 196_ KYMSH 201_ LASCG 206_ MGLLL 211_ TVDPG 216_ SGTVL 221_ WTQDL 226_ GVPVM 231_ GVYTW 236_ HQDGL 241_ RQLPH 246_ LTLAR 251_ DTLHF 256_ LALRW 261_ GHIRL 266_ PASGP 271_ RDTAT 276_ LFSTL 281_ DTQLL 286_ MTLYV 291_ GKDET 296_ GFYVS 301_ KALVH 306_ TGVAL 311_ VPRGL 316_ TLAPA 321_ DGPTT 326_ DEVTL 331_ QVSGE 336_ REGSP 341_ STAVR 346_ YPSGS 351_ VALPS 356_ QWLLI 361_ GHHEL 366_ PPVLH 371_ TTMLR 376_ VHPTL 381_ GSGTA 386_ ETRPP 391_ ENTQA 396_ PAFFL 401_ ELLSL 406_ SREKL 411_ WDSEL 416_ HPEEK 421_ TPDSY 426_ LGLGP 431_ QDLLA 436_ ASLTA 441_ VLLGG 446_ WILFV 451_ MRQQQ 456_ PQVVE 461_ KQQET 466_ PLAPA 471_ DFAHI 476_ SQDAQ 481_ SLHSG 486_ ASRRS 491_ QKRLQ 496_ SPSKQ 501_ AQPLD 506_ DPEAE 511_ QLTVV 516_ GKISF 521_ NPKDV 526_ LGRGA 531_ GGTFV 536_ FRGQF 541_ EGRAV 546_ AVKRL 551_ LRECF 556_ GLVRR 561_ EVQLL 566_ QESDR 571_ HPNVL 576_ RYFCT 581_ ERGPQ 586_ FHYIA 591_ LELCR 596_ ASLQE 601_ YVENP 606_ DLDRG 611_ GLEPE 616_ VVLQQ 621_ LMSGL 626_ AHLHS 631_ LHIVH 636_ RDLKP 641_ GNILI 646_ TGPDS 651_ QGLGR 656_ VVLSD 661_ FGLCK 666_ KLPAG 671_ RCSFS 676_ LHSGI 681_ PGTEG 686_ WMAPE 691_ LLQLL 696_ PPDSP 701_ TSAVD 706_ IFSAG 711_ CVFYY 716_ VLSGG 721_ SHPFG 726_ DSLYR 731_ QANIL 736_ TGAPC 741_ LAHLE 746_ EEVHD 751_ KVVAR 756_ DLVGA 761_ MLSPL 766_ PQPRP 771_ SAPQV 776_ LAHPF 781_ FWSRA 786_ KQLQF 791_ FQDVS 796_ DWLEK 801_ ESEQE 806_ PLVRA 811_ LEAGG 816_ CAVVR 821_ DNWHE 826_ HISMP 831_ LQTDL 836_ RKFRS 841_ YKGTS 846_ VRDLL 851_ RAVRN 856_ KKHHY 861_ RELPV 866_ EVRQA 871_ LGQVP 876_ DGFVQ 881_ YFTNR 886_ FPRLL 891_ LHTHR 896_ AMRSC 901_ ASESL 906_ FLPYY 911_ PPDSE 916_ ARRPC 921_PGATG
1: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins