E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
1_MLLHL 6_ CSVKN 11_ LYQNR 16_ FLGLA 21_ AMASP 26_ SRNSQ 31_ SRRRC 36_ KEPLR 41_ YSYNP 46_ DQFHN 51_ MDLRG 56_ GPHDG 61_ VTIPR 66_ STSDT 71_ DLVTS 76_ DSRST 81_ LMVSS 86_ SYYSI 91_ GHSQD 96_ LVIHW 101_ DIKEE 106_ VDAGD 111_ WIGMY 116_ LIDEV 121_ LSENF 126_ LDYKN 131_ RGVNG 136_ SHRGQ 141_ IIWKI 146_ DASSY 151_ FVEPE 156_ TKICF 161_ KYYHG 166_ VSGAL 171_ RATTP 176_ SVTVK 181_ NSAAP 186_ IFKSI 191_ GADET 196_ VQGQG 201_ SRRLI 206_ SFSLS 211_ DFQAM 216_ GLKKG 221_ MFFNP 226_ DPYLK 231_ ISIQP 236_ GKHSI 241_ FPALP 246_ HHGQE 251_ RRSKI 256_ IGNTV 261_ NPIWQ 266_ AEQFS 271_ FVSLP 276_ TDVLE 281_ IEVKD 286_ KFAKS 291_ RPIIK 296_ RFLGK 301_ LSMPV 306_ QRLLE 311_ RHAIG 316_ DRVVS 321_ YTLGR 326_ RLPTD 331_ HVSGQ 336_ LQFRF 341_ EITSS 346_ IHPDD 351_ EEISL 356_ STEPE 361_ SAQIQ 366_ DSPMN 371_ NLMES 376_ GSGEP 381_ RSEAP 386_ ESSES 391_ WKPEQ 396_ LGEGS 401_ VPDGP 406_ GNQSI 411_ ELSRP 416_ AEEAA 421_ VITEA 426_ GDQGM 431_ VSVGP 436_ EGAGE 441_ LLAQV 446_ QKDIQ 451_ PAPSA 456_ EELAE 461_ QLDLG 466_ EEASA 471_ LLLED 476_ GEAPA 481_ STKEE 486_ PLEEE 491_ ATTQS 496_ RAGRE 501_ EEEKE 506_ QEEEG 511_ DVSTL 516_ EQGEG 521_ RLQLR 526_ ASVKR 531_ KSRPC 536_ SLPVS 541_ ELETV 546_ IASAC 551_ GDPET 556_ PRTHY 561_ IRIHT 566_ LLHSM 571_ PSAQG 576_ GSAAE 581_ EEDGA 586_ EEEST 591_ LKDSS 596_ EKDGL 601_ SEVDT 606_ VAADP 611_ SALEE 616_ DREEP 621_ EGATP 626_ GTAHP 631_ GHSGG 636_ HFPSL 641_ ANGAA 646_ QDGDT 651_ HPSTG 656_ SESDS 661_ SPRQG 666_ GDHSC 671_ EGCDA 676_ SCCSP 681_ SCYSS 686_ SCYST 691_ SCYSS 696_ SCYSA 701_ SCYSP 706_ SCYNG 711_ NRFAS 716_ HTRFS 721_ SVDSA 726_ KISES 731_ TVFSS 736_ QDDEE 741_ EENSA 746_ FESVP 751_ DSMQS 756_ PELDP 761_ ESTNG 766_ AGPWQ 771_ DELAA 776_ PSGHV 781_ ERSPE 786_ GLESP 791_ VAGPS 796_ NRREG 801_ ECPIL 806_ HNSQP 811_ VSQLP 816_ SLRPE 821_ HHHYP 826_ TIDEP 831_ LPPNW 836_ EARID 841_ SHGRV 846_ FYVDH 851_ VNRTT 856_ TWQRP 861_ TAAAT 866_ PDGMR 871_ RSGSI 876_ QQMEQ 881_ LNRRY 886_ QNIQR 891_ TIATE 896_ RSEED 901_ SGSQS 906_ CEQAP 911_ AGGGG 916_ GGGSD 921_ SEAES 926_ SQSSL 931_ DLRRE 936_ GSLSP 941_ VNSQK 946_ ITLLL 951_ QSPAV 956_ KFITN 961_ PEFFT 966_ VLHAN 971_ YSAYR 976_ VFTSS 981_ TCLKH 986_ MILKV 991_ RRDAR 996_ NFERY 1001_ QHNRD 1006_ LVNFI 1011_ NMFAD 1016_ TRLEL 1021_ PRGWE 1026_ IKTDQ 1031_ QGKSF 1036_ FVDHN 1041_ SRATT 1046_ FIDPR 1051_ IPLQN 1056_ GRLPN 1061_ HLTHR 1066_ QHLQR 1071_ LRSYS 1076_ AGEAS 1081_ EVSRN 1086_ RGASL 1091_ LARPG 1096_ HSLVA 1101_ AIRSQ 1106_ HQHES 1111_ LPLAY 1116_ NDKIV 1121_ AFLRQ 1126_ PNIFE 1131_ MLQER 1136_ QPSLA 1141_ RNHTL 1146_ REKIH 1151_ YIRTE 1156_ GNHGL 1161_ EKLSC 1166_ DADLV 1171_ ILLSL 1176_ FEEEI 1181_ MSYVP 1186_ LQAAF 1191_ HPGYS 1196_ FSPRC 1201_ SPCSS 1206_ PQNSP 1211_ GLQRA 1216_ SARAP 1221_ SPYRR 1226_ DFEAK 1231_ LRNFY 1236_ RKLEA 1241_ KGFGQ 1246_ GPGKI 1251_ KLIIR 1256_ RDHLL 1261_ EGTFN 1266_ QVMAY 1271_ SRKEL 1276_ QRNKL 1281_ YVTFV 1286_ GEEGL 1291_ DYSGP 1296_ SREFF 1301_ FLLSQ 1306_ ELFNP 1311_ YYGLF 1316_ EYSAN 1321_ DTYTV 1326_ QISPM 1331_ SAFVE 1336_ NHLEW 1341_ FRFSG 1346_ RILGL 1351_ ALIHQ 1356_ YLLDA 1361_ FFTRP 1366_ FYKAL 1371_ LRLPC 1376_ DLSDL 1381_ EYLDE 1386_ EFHQS 1391_ LQWMK 1396_ DNNIT 1401_ DILDL 1406_ TFTVN 1411_ EEVFG 1416_ QVTER 1421_ ELKSG 1426_ GANTQ 1431_ VTEKN 1436_ KKEYI 1441_ ERMVK 1446_ WRVER 1451_ GVVQQ 1456_ TEALV 1461_ RGFYE 1466_ VVDSR 1471_ LVSVF 1476_ DAREL 1481_ ELVIA 1486_ GTAEI 1491_ DLNDW 1496_ RNNTE 1501_ YRGGY 1506_ HDGHL 1511_ VIRWF 1516_ WAAVE 1521_ RFNNE 1526_ QRLRL 1531_ LQFVT 1536_ GTSSV 1541_ PYEGF 1546_ AALRG 1551_ SNGLR 1556_ RFCIE 1561_ KWGKI 1566_ TSLPR 1571_ AHTCF 1576_ NRLDL 1581_ PPYPS 1586_ YSMLY 1591_ EKLLT 1596_ AVEET 1601_STFGL
1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS