Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)
1_MSDFV 6_ ESEAE 11_ ESEEE 16_ YNDEG 21_ EVVPR 26_ VTKKF 31_ VEEED 36_ DDEEE 41_ EEENL 46_ DDQDE 51_ QGNLK 56_ GFIND 61_ DDDED 66_ EGEED 71_ EGSDS 76_ GDSED 81_ DVGHK 86_ KRKRT 91_ SFDDR 96_ LEDDD 101_ FDLIE 106_ ENLGV 111_ KVKRG 116_ QKYRR 121_ VKKMS 126_ DDEDD 131_ DEEEY 136_ GKEEH 141_ EKEAI 146_ AEEIF 151_ QDGEG 156_ EEGQE 161_ AMEAP 166_ MAPPE 171_ EEEED 176_ DEESD 181_ IDDFI 186_ VDDDG 191_ QPLKK 196_ PKWRK 201_ KLPGY 206_ TDAAL 211_ QEAQE 216_ IFGVD 221_ FDYDE 226_ FEKYN 231_ EYDEE 236_ LEEEY 241_ EYEDD 246_ EAEGE 251_ IRVRP 256_ KKTTK 261_ KRVSR 266_ RSIFE 271_ MYEPS 276_ ELESS 281_ HLTDQ 286_ DNEIR 291_ ATDLP 296_ ERFQL 301_ RSIPV 306_ KGAED 311_ DELEE 316_ EADWI 321_ YRNAF 326_ ATPTI 331_ SLQES 336_ CDYLD 341_ RGQPA 346_ SSFSR 351_ KGPST 356_ IQKIK 361_ EALGF 366_ MRNQH 371_ FEVPF 376_ IAFYR 381_ KEYVE 386_ PELHI 391_ NDLWR 396_ VWQWD 401_ EKWTQ 406_ LRIRK 411_ ENLTR 416_ LFEKM 421_ QAYQY 426_ EQISA 431_ DPDKP 436_ LADGI 441_ RALDT 446_ TDMER 451_ LKDVQ 456_ SMDEL 461_ KDVYN 466_ HFLLY 471_ YGRDI 476_ PKMQN 481_ AAKAS 486_ RKKLK 491_ RVREE 496_ GDEEG 501_ EGDEA 506_ EDEEQ 511_ RGPEL 516_ KQASR 521_ RDMYT 526_ ICQSA 531_ GLDGL 536_ AKKFG 541_ LTPEQ 546_ FGENL 551_ RDSYQ 556_ RHETE 561_ QFPAE 566_ PLELA 571_ KDYVC 576_ SQFPT 581_ PEAVL 586_ EGARY 591_ MVALQ 596_ IAREP 601_ LVRQV 606_ LRQTF 611_ QERAK 616_ LNITP 621_ TKKGR 626_ KDVDE 631_ AHYAY 636_ SFKYL 641_ KNKPV 646_ KELRD 651_ DQFLK 656_ ICLAE 661_ DEGLL 666_ TTDIS 671_ IDLKG 676_ VEGYG 681_ NDQTY 686_ FEEIK 691_ QFYYR 696_ DEFSH 701_ QVQEW 706_ NRQRT 711_ MAIER 716_ ALQQF 721_ LYVQM 726_ AKELK 731_ NKLLA 736_ EAKEY 741_ VIKAC 746_ SRKLY 751_ NWLRV 756_ APYRP 761_ DQQVE 766_ EDDDF 771_ MDENQ 776_ GKGIR 781_ VLGIA 786_ FSSAR 791_ DHPVF 796_ CALVN 801_ GEGEV 806_ TDFLR 811_ LPHFT 816_ KRRTA 821_ WREEE 826_ REKKA 831_ QDIET 836_ LKKFL 841_ LNKKP 846_ HVVTV 851_ AGENR 856_ DAQML 861_ IEDVK 866_ RIVHE 871_ LDQGQ 876_ QLSSI 881_ GVELV 886_ DNELA 891_ ILYMN 896_ SKKSE 901_ AEFRD 906_ YPPVL 911_ RQAVS 916_ LARRI 921_ QDPLI 926_ EFAQV 931_ CSSDE 936_ DILCL 941_ KFHPL 946_ QEHVV 951_ KEELL 956_ NALYC 961_ EFINR 966_ VNEVG 971_ VDVNR 976_ AIAHP 981_ YSQAL 986_ IQYVC 991_ GLGPR 996_ KGTHL 1001_ LKILK 1006_ QNNTR 1011_ LESRT 1016_ QLVTM 1021_ CHMGP 1026_ KVFMN 1031_ CAGFL 1036_ KIDTA 1041_ SLGDS 1046_ TDSYI 1051_ EVLDG 1056_ SRVHP 1061_ ETYEW 1066_ ARKMA 1071_ VDALE 1076_ YDESA 1081_ EDANP 1086_ AGALE 1091_ EILEN 1096_ PERLK 1101_ DLDLD 1106_ AFAEE 1111_ LERQG 1116_ YGDKH 1121_ ITLYD 1126_ IRAEL 1131_ SCRYK 1136_ DLRTA 1141_ YRSPN 1146_ TEEIF 1151_ NMLTK 1156_ ETPET 1161_ FYIGK 1166_ LIICN 1171_ VTGIA 1176_ HRRPQ 1181_ GESYD 1186_ QAIRN 1191_ DETGL 1196_ WQCPF 1201_ CQQDN 1206_ FPELS 1211_ EVWNH 1216_ FDSGS 1221_ CPGQA 1226_ IGVKT 1231_ RLDNG 1236_ VTGFI 1241_ PTKFL 1246_ SDKVV 1251_ KRPEE 1256_ RVKVG 1261_ MTVHC 1266_ RIMKI 1271_ DIEKF 1276_ SADLT 1281_ CRTSD 1286_ LMDRN 1291_ NEWKL 1296_ PKDTY 1301_ YDFDA 1306_ EAADH 1311_ KQEED 1316_ MKRKQ 1321_ QRTTY 1326_ IKRVI 1331_ AHPSF 1336_ HNINF 1341_ KQAEK 1346_ MMETM 1351_ DQGDV 1356_ IIRPS 1361_ SKGEN 1366_ HLTVT 1371_ WKVSD 1376_ GIYQH 1381_ VDVRE 1386_ EGKEN 1391_ AFSLG 1396_ ATLWI 1401_ NSEEF 1406_ EDLDE 1411_ IVARY 1416_ VQPMA 1421_ SFARD 1426_ LLNHK 1431_ YYQDC 1436_ SGGDR 1441_ KKLEE 1446_ LLIKT 1451_ KKEKP 1456_ TFIPY 1461_ FICAC 1466_ KELPG 1471_ KFLLG 1476_ YQPRG 1481_ KPRIE 1486_ YVTVT 1491_ PEGFR 1496_ YRGQI 1501_ FPTVN 1506_ GLFRW 1511_ FKDHY 1516_ QDPVP 1521_ GITPS 1526_ SSSRT 1531_ RTPAS 1536_ INATP 1541_ ANINL 1546_ ADLTR 1551_ AVNAL 1556_ PQNMT 1561_ SQMFS 1566_ AIAAV 1571_ TGQGQ 1576_ NPNAT 1581_ PAQWA 1586_ SSQYG 1591_ YGGSG 1596_ GGSSA 1601_ YHVFP 1606_ TPAQQ 1611_ PVATP 1616_ LMTPS 1621_ YSYTT 1626_ PSQPI 1631_ TTPQY 1636_ HQLQA 1641_ STTPQ 1646_ SAQAQ 1651_ PQPSS 1656_ SSRQR 1661_ QQQPK 1666_ SNSHA 1671_ AIDWG 1676_ KMAEQ 1681_ WLQEK 1686_ EAERR 1691_ KQKQR 1696_ LTPRP 1701_ SPSPM 1706_ IESTP 1711_ MSIAG 1716_ DATPL 1721_LDEMD
1: Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A