Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)
1_MASSA 6_ QSGGS 11_ SGGPA 16_ VPTVQ 21_ RGIIK 26_ MVLSG 31_ CAIIV 36_ RGQPR 41_ GGPPP 46_ ERQIN 51_ LSNIR 56_ AGNLA 61_ RRAAA 66_ TQPDA 71_ KDTPD 76_ EPWAF 81_ PAREF 86_ LRKKL 91_ IGKEV 96_ CFTIE 101_ NKTPQ 106_ GREYG 111_ MIYLG 116_ KDTNG 121_ ENIAE 126_ SLVAE 131_ GLATR 136_ REGMR 141_ ANNPE 146_ QNRLS 151_ ECEEQ 156_ AKAAK 161_ KGMWS 166_ EGNGS 171_ HTIRD 176_ LKYTI 181_ ENPRH 186_ FVDSH 191_ HQKPV 196_ NAIIE 201_ HVRDG 206_ SVVRA 211_ LLLPD 216_ YYLVT 221_ VMLSG 226_ IKCPT 231_ FRREA 236_ DGSET 241_ PEPFA 246_ AEAKF 251_ FTESR 256_ LLQRD 261_ VQIIL 266_ ESCHN 271_ QNILG 276_ TILHP 281_ NGNIT 286_ ELLLK 291_ EGFAR 296_ CVDWS 301_ IAVYT 306_ RGAEK 311_ LRAAE 316_ RFAKE 321_ RRLRI 326_ WRDYV 331_ APTAN 336_ LDQKD 341_ KQFVA 346_ KVMQV 351_ LNADA 356_ IVVKL 361_ NSGDY 366_ KTIHL 371_ SSIRP 376_ PRLEG 381_ ENTQD 386_ KNKKL 391_ RPLYD 396_ IPYMF 401_ EAREF 406_ LRKKL 411_ IGKKV 416_ NVTVD 421_ YIRPA 426_ SPATE 431_ TVPAF 436_ SERTC 441_ ATVTI 446_ GGINI 451_ AEALV 456_ SKGLA 461_ TVIRY 466_ RQDDD 471_ QRSSH 476_ YDELL 481_ AAEAR 486_ AIKNG 491_ KGLHS 496_ KKEVP 501_ IHRVA 506_ DISGD 511_ TQKAK 516_ QFLPF 521_ LQRAG 526_ RSEAV 531_ VEYVF 536_ SGSRL 541_ KLYLP 546_ KETCL 551_ ITFLL 556_ AGIEC 561_ PRGAR 566_ NLPGL 571_ VQEGE 576_ PFSEE 581_ ATLFT 586_ KELVL 591_ QREVE 596_ VEVES 601_ MDKAG 606_ NFIGW 611_ LHIDG 616_ ANLSV 621_ LLVEH 626_ ALSKV 631_ HFTAE 636_ RSSYY 641_ KSLLS 646_ AEEAA 651_ KQKKE 656_ KVWAH 661_ YEEQP 666_ VEEVM 671_ PVLEE 676_ KERSA 681_ SYKPV 686_ FVTEI 691_ TDDLH 696_ FYVQD 701_ VETGT 706_ QLEKL 711_ MENMR 716_ NDIAS 721_ HPPVE 726_ GSYAP 731_ RRGEF 736_ CIAKF 741_ VDGEW 746_ YRARV 751_ EKVES 756_ PAKIH 761_ VFYID 766_ YGNRE 771_ VLPST 776_ RLGTL 781_ SPAFS 786_ TRVLP 791_ AQATE 796_ YAFAF 801_ IQVPQ 806_ DDDAR 811_ TDAVD 816_ SVVRD 821_ IQNTQ 826_ CLLNV 831_ EHLSA 836_ GCPHV 841_ TLQFA 846_ DSKGD 851_ VGLGL 856_ VKEGL 861_ VMVEV 866_ RKEKQ 871_ FQKVI 876_ TEYLN 881_ AQESA 886_ KSARL 891_ NLWRY 896_ GDFRA 901_DDADE
1: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity)
2: (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2)
3: (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9