Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
1_MSSAR 6_ TPLPT 11_ LNERD 16_ TEQPT 21_ LGHLD 26_ SKPSS 31_ KSNMI 36_ RGRNS 41_ ATSAD 46_ EQPHI 51_ GNYRL 56_ LKTIG 61_ KGNFA 66_ KVKLA 71_ RHILT 76_ GKEVA 81_ VKIID 86_ KTQLN 91_ SSSLQ 96_ KLFRE 101_ VRIMK 106_ VLNHP 111_ NIVKL 116_ FEVIE 121_ TEKTL 126_ YLVME 131_ YASGG 136_ EVFDY 141_ LVAHG 146_ RMKEK 151_ EARAK 156_ FRQIV 161_ SAVQY 166_ CHQKF 171_ IVHRD 176_ LKAEN 181_ LLLDA 186_ DMNIK 191_ IADFG 196_ FSNEF 201_ TFGNK 206_ LDTFC 211_ GSPPY 216_ AAPEL 221_ FQGKK 226_ YDGPE 231_ VDVWS 236_ LGVIL 241_ YTLVS 246_ GSLPF 251_ DGQNL 256_ KELRE 261_ RVLRG 266_ KYRIP 271_ FYMST 276_ DCENL 281_ LKKFL 286_ ILNPS 291_ KRGTL 296_ EQIMK 301_ DRWMN 306_ VGHED 311_ DELKP 316_ YVEPL 321_ PDYKD 326_ PRRTE 331_ LMVSM 336_ GYTRE 341_ EIQDS 346_ LVGQR 351_ YNEVM 356_ ATYLL 361_ LGYKS 366_ SELEG 371_ DTITL 376_ KPRPS 381_ ADLTN 386_ SSAPS 391_ PSHKV 396_ QRSVS 401_ ANPKQ 406_ RRFSD 411_ QAAGP 416_ AIPTS 421_ NSYSK 426_ KTQSN 431_ NAENK 436_ RPEED 441_ RESGR 446_ KASST 451_ AKVPA 456_ SPLPG 461_ LERKK 466_ TTPTP 471_ STNSV 476_ LSTST 481_ NRSRN 486_ SPLLE 491_ RASLG 496_ QASIQ 501_ NGKDS 506_ LTMPG 511_ SRAST 516_ ASASA 521_ AVSAA 526_ RPRQH 531_ QKSMS 536_ ASVHP 541_ NKASG 546_ LPPTE 551_ SNCEV 556_ PRPST 561_ APQRV 566_ PVASP 571_ SAHNI 576_ SSSGG 581_ APDRT 586_ NFPRG 591_ VSSRS 596_ TFHAG 601_ QLRQV 606_ RDQQN 611_ LPYGV 616_ TPASP 621_ SGHSQ 626_ GRRGA 631_ SGSIF 636_ SKFTS 641_ KFVRR 646_ NLSFR 651_ FARRN 656_ LNEPE 661_ SKDRV 666_ ETLRP 671_ HVVGS 676_ GGNDK 681_ EKEEF 686_ REAKP 691_ RSLRF 696_ TWSMK 701_ TTSSM 706_ EPNEM 711_ MREIR 716_ KVLDA 721_ NSCQS 726_ ELHEK 731_ YMLLC 736_ MHGTP 741_ GHEDF 746_ VQWEM 751_ EVCKL 756_ PRLSL 761_ NGVRF 766_ KRISG 771_ TSMAF 776_ KNIAS 781_KIANE
1: Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells