Cytochrome c oxidase assembly protein COX15 homolog
1_MQRLL 6_ FPPLR 11_ ALKGR 16_ QYLPL 21_ LAPRA 26_ APRAQ 31_ CDCIR 36_ RPLRP 41_ GQYST 46_ ISEVA 51_ LQSGR 56_ GTVSL 61_ PSKAA 66_ ERVVG 71_ RWLLV 76_ CSGTV 81_ AGAVI 86_ LGGVT 91_ RLTES 96_ GLSMV 101_ DWHLI 106_ KEMKP 111_ PTSQE 116_ EWEAE 121_ FQRYQ 126_ QFPEF 131_ KILNH 136_ DMTLT 141_ EFKFI 146_ WYMEY 151_ SHRMW 156_ GRLVG 161_ LVYIL 166_ PAAYF 171_ WRKGW 176_ LSRGM 181_ KGRVL 186_ ALCGL 191_ VCFQG 196_ LLGWY 201_ MVKSG 206_ LEEKS 211_ DSHDI 216_ PRVSQ 221_ YRLAA 226_ HLGSA 231_ LVLYC 236_ ASLWT 241_ SLSLL 246_ LPPHK 251_ LPETH 256_ QLLQL 261_ RRFAH 266_ GTAGL 271_ VFLTA 276_ LSGAF 281_ VAGLD 286_ AGLVY 291_ NSFPK 296_ MGESW 301_ IPEDL 306_ FTFSP 311_ ILRNV 316_ FENPT 321_ MVQFD 326_ HRILG 331_ ITSVT 336_ AITVL 341_ YFLSR 346_ RIPLP 351_ RRTKM 356_ AAVTL 361_ LALAY 366_ TQVGL 371_ GISTL 376_ LMYVP 381_ TPLAA 386_ THQSG 391_ SLALL 396_ TGALW 401_LMNEL
1: Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO) (PubMed:12474143). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A (By similarity)