Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)
1_MGRES 6_ RHYRK 11_ RSASR 16_ GRSGS 21_ RSRSR 26_ SPSDK 31_ RSKRG 36_ DDRRS 41_ RSRDR 46_ DRRRE 51_ RSRSR 56_ DKRRS 61_ RSRDR 66_ KRLRR 71_ SRSRE 76_ RDRSR 81_ ERRRS 86_ RSRDR 91_ RRSRS 96_ RSRGR 101_ RSRSS 106_ SPGNK 111_ SKKTE 116_ NRSRS 121_ KEKTD 126_ GGESS 131_ KEKKK 136_ DKDDK 141_ EDEKE 146_ KDAGN 151_ FDQNK 156_ LEEEM 161_ RKRKE 166_ RVEKW 171_ REEQR 176_ KKAME 181_ NIGEL 186_ KKEIE 191_ EMKQG 196_ KKWSL 201_ EDDDD 206_ DEDDP 211_ AEAEK 216_ EGNEM 221_ EGEEL 226_ DPLDA 231_ YMEEV 236_ KEEVK 241_ KFNMR 246_ SVKGG 251_ GGNEK 256_ KSGPT 261_ VTKVV 266_ TVVTT 271_ KKAVV 276_ DSDKK 281_ KGELM 286_ ENDQD 291_ AMEYS 296_ SEEEE 301_ VDLQT 306_ ALTGY 311_ QTKQR 316_ KLLEP 321_ VDHGK 326_ IEYEP 331_ FRKNF 336_ YVEVP 341_ ELAKM 346_ SQEEV 351_ NVFRL 356_ EMEGI 361_ TVKGK 366_ GCPKP 371_ IKSWV 376_ QCGIS 381_ MKILN 386_ SLKKH 391_ GYEKP 396_ TPIQT 401_ QAIPA 406_ IMSGR 411_ DLIGI 416_ AKTGS 421_ GKTIA 426_ FLLPM 431_ FRHIM 436_ DQRSL 441_ EEGEG 446_ PIAVI 451_ MTPTR 456_ ELALQ 461_ ITKEC 466_ KKFSK 471_ TLGLR 476_ VVCVY 481_ GGTGI 486_ SEQIA 491_ ELKRG 496_ AEIIV 501_ CTPGR 506_ MIDML 511_ AANSG 516_ RVTNL 521_ RRVTY 526_ VVLDE 531_ ADRMF 536_ DMGFE 541_ PQVMR 546_ IVDNV 551_ RPDRQ 556_ TVMFS 561_ ATFPR 566_ AMEAL 571_ ARRIL 576_ SKPIE 581_ VQVGG 586_ RSVVC 591_ SDVEQ 596_ QVIVI 601_ EEEKK 606_ FLKLL 611_ ELLGH 616_ YQESG 621_ SVIIF 626_ VDKQE 631_ HADGL 636_ LKDLM 641_ RASYP 646_ CMSLH 651_ GGIDQ 656_ YDRDS 661_ IINDF 666_ KNGTC 671_ KLLVA 676_ TSVAA 681_ RGLDV 686_ KHLIL 691_ VVNYS 696_ CPNHY 701_ EDYVH 706_ RAGRT 711_ GRAGN 716_ KGYAY 721_ TFITE 726_ DQARY 731_ AGDII 736_ KALEL 741_ SGTAV 746_ PPDLE 751_ KLWSD 756_ FKDQQ 761_ KAEGK 766_ IIKKS 771_ SGFSG 776_ KGFKF 781_ DETEQ 786_ ALANE 791_ RKKLQ 796_ KAALG 801_ LQDSD 806_ DEDAA 811_ VDIDE 816_ QIESM 821_ FNSKK 826_ RVKDM 831_ AAPGT 836_ SSVPA 841_ PTAGN 846_ AEKLE 851_ IAKRL 856_ ALRIN 861_ AQKNL 866_ GIESQ 871_ DVMQQ 876_ ATNAI 881_ LRGGT 886_ ILAPT 891_ VSAKT 896_ IAEQL 901_ AEKIN 906_ AKLNY 911_ VPLEK 916_ QEEER 921_ QDGGQ 926_ NESFK 931_ RYEEE 936_ LEIND 941_ FPQTA 946_ RWKVT 951_ SKEAL 956_ QRISE 961_ YSEAA 966_ ITIRG 971_ TYFPP 976_ GKEPK 981_ EGERK 986_ IYLAI 991_ ESANE 996_ LAVQK 1001_ AKAEI 1006_ TRLIK 1011_ EELIR 1016_ LQNSY 1021_ QPTNK 1026_GRYKV
1: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:32494006, PubMed:34822310, PubMed:36797247). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site (PubMed:34822310)