Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar)
1_MSALT 6_ PPTDM 11_ PTPTT 16_ DKITQ 21_ AAMET 26_ IYLCK 31_ FRVSM 36_ DGEWL 41_ CLREL 46_ DDISL 51_ TPDPE 56_ PTHED 61_ PNYLM 66_ ANERM 71_ NLMNM 76_ AKLSI 81_ KGLIE 86_ SALNL 91_ GRTLD 96_ SDYAP 101_ LQQFF 106_ VVMEH 111_ CLKHG 116_ LKAKK 121_ TFLGQ 126_ NKSFW 131_ GPLEL 136_ VEKLV 141_ PEAAE 146_ ITASV 151_ KDLPG 156_ LKTPV 161_ GRGRA 166_ WLRLA 171_ LMQKK 176_ LSEYM 181_ KALIN 186_ KKELL 191_ SEFYE 196_ PNALM 201_ MEEEG 206_ AIIAG 211_ LLVGL 216_ NVIDA 221_ NFCMK 226_ GEDLD 231_ SQVGV 236_ IDFSM 241_ YLKDG 246_ NSSKG 251_ TEGDG 256_ QITAI 261_ LDQKN 266_ YVEEL 271_ NRHLN 276_ ATVNN 281_ LQAKV 286_ DALEK 291_ SNTKL 296_ TEELA 301_ VANNR 306_ IITLQ 311_ EEMER 316_ VKEES 321_ SYILE 326_ SNRKG 331_ PKQDR 336_ TAEGQ 341_ ALSEA 346_ RKHLK 351_ EETQL 356_ RLDVE 361_ KELEM 366_ QISMR 371_ QEMEL 376_ AMKML 381_ EKDVC 386_ EKQDA 391_ LVSLR 396_ QQLDD 401_ LRALK 406_ HELAF 411_ KLQSS 416_ DLGVK 421_ QKSEL 426_ NSRLE 431_ EKTNQ 436_ MAATI 441_ KQLEQ 446_ SEKDL 451_ VKQAK 456_ TLNSA 461_ANKLI
1: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (PubMed:35314674). Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity)