Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
1_MPPQQ 6_ GDPAF 11_ PDRCE 16_ APPVP 21_ PRRER 26_ GGRGG 31_ RGPGE 36_ PGGRG 41_ RAGGA 46_ EGRGV 51_ KCVLV 56_ GDGAV 61_ GKTSL 66_ VVSYT 71_ TNGYP 76_ TEYIP 81_ TAFDN 86_ FSAVV 91_ SVDGR 96_ PVRLQ 101_ LCDTA 106_ GQDEF 111_ DKLRP 116_ LCYTN 121_ TDIFL 126_ LCFSV 131_ VSPSS 136_ FQNVS 141_ EKWVP 146_ EIRCH 151_ CPKAP 156_ IILVG 161_ TQSDL 166_ REDVK 171_ VLIEL 176_ DKCKE 181_ KPVPE 186_ EAAKL 191_ CAEEI 196_ KAASY 201_ IECSA 206_ LTQKN 211_ LKEVF 216_ DAAIV 221_ AGIQY 226_ SDTQQ 231_ QPKKS 236_ KSRTP 241_ DKMKN 246_ LSKSW 251_WKKYC
1: Binds to and activates protein kinase PAK1 (PubMed:11459829). Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration (PubMed:11459829, PubMed:17620058, PubMed:18086875, PubMed:21834987). Also stimulates quiescent cells to reenter the cell cycle (PubMed:11459829). Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound (PubMed:16472646)