Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R)
1_MLNVP 6_ SQSFP 11_ APRSQ 16_ QRVAS 21_ GGRSK 26_ VPLKQ 31_ GRSLM 36_ DWIRL 41_ TKSGK 46_ DLTGL 51_ KGRLI 56_ EVTEE 61_ ELKKH 66_ NKKDD 71_ CWICI 76_ RGFVY 81_ NVSPY 86_ MEYHP 91_ GGEDE 96_ LMRAA 101_ GSDGT 106_ ELFDQ 111_ VHRWV 116_ NYESM 121_ LKECL 126_ VGRMA 131_ IKPAV 136_ LKDYR 141_ EEEKK 146_ VLNGM 151_ LPKSQ 156_ VTDTL 161_ AKEGP 166_ SYPSY 171_ DWFQT 176_ DSLVT 181_ IAIYT 186_ KQKDI 191_ NLDSI 196_ IVDHQ 201_ NDSFR 206_ AETII 211_ KDCLY 216_ LIHIG 221_ LSHEV 226_ QEDFS 231_ VRVVE 236_ SVGKI 241_ EIVLQ 246_ KKENT 251_ SWDFL 256_ GHPLK 261_ NHNSL 266_ IPRKD 271_ TGLYY 276_ RKCQL 281_ ISKED 286_ VTHDT 291_ RLFCL 296_ MLPPS 301_ THLQV 306_ PIGQH 311_ VYLKL 316_ PITGT 321_ EIVKP 326_ YTPVS 331_ GSLLS 336_ EFKEP 341_ VLPNN 346_ KYIYF 351_ LIKIY 356_ PTGLF 361_ TPELD 366_ RLQIG 371_ DFVSV 376_ SSPEG 381_ NFKIS 386_ KFQEL 391_ EDLFL 396_ LAAGT 401_ GFTPM 406_ VKILN 411_ YALTD 416_ IPSLR 421_ KVKLM 426_ FFNKT 431_ EDDII 436_ WRSQL 441_ EKLAF 446_ KDKRL 451_ DVEFV 456_ LSAPI 461_ SEWNG 466_ KQGHI 471_ SPALL 476_ SEFLK 481_ RNLDK 486_ SKVLV 491_ CICGP 496_ VPFTE 501_ QGVRL 506_ LHDLN 511_ FSKNE 516_IHSFT
1: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin