Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D)
1_MFTLA 6_ EVASL 11_ NDIQP 16_ TYRIL 21_ KPWWD 26_ VFMDY 31_ LAVVM 36_ LMVAI 41_ FAGTM 46_ QLTKD 51_ QVVCL 56_ PVLPS 61_ PVNSK 66_ AHTPP 71_ GNAEV 76_ TTNIP 81_ KMEAA 86_ TNQDQ 91_ DGRTT 96_ NDISF 101_ GTSAV 106_ TPDIP 111_ LRATY 116_ PRTDF 121_ ALPNQ 126_ EAKKE 131_ KKDPT 136_ GRKTN 141_ LDFQQ 146_ YVFIN 151_ QMCYH 156_ LALPW 161_ YSKYF 166_ PYLAL 171_ IHTII 176_ LMVSS 181_ NFWFK 186_ YPKTC 191_ SKVEH 196_ FVSIL 201_ GKCFE 206_ SPWTT 211_ KALSE 216_ TACED 221_ SEENK 226_ QRITG 231_ AQTLP 236_ KHVST 241_ SSDEG 246_ SPSAS 251_ TPMIN 256_ KTGFK 261_ FSAEK 266_ PVIEV 271_ PSMTI 276_ LDKKD 281_ GEQAK 286_ ALFEK 291_ VRKFR 296_ AHVED 301_ SDLIY 306_ KLYVV 311_ QTVIK 316_ TAKFI 321_ FILCY 326_ TANFV 331_ NAISF 336_ EHVCK 341_ PKVEH 346_ LIGYE 351_ VFECT 356_ HNMAY 361_ MLKKL 366_ LISYI 371_ SIICV 376_ YGFIC 381_ LYTLF 386_ WLFRI 391_ PLKEY 396_ SFEKV 401_ REESS 406_ FSDIP 411_ DVKND 416_ FAFLL 421_ HMVDQ 426_ YDQLY 431_ SKRFG 436_ VFLSE 441_ VSENK 446_ LREIS 451_ LNHEW 456_ TFEKL 461_ RQHIS 466_ RNAQD 471_ KQELH 476_ LFMLS 481_ GVPDA 486_ VFDLT 491_ DLDVL 496_ KLELI 501_ PEAKI 506_ PAKIS 511_ QMTNL 516_ QELHL 521_ CHCPA 526_ KVEQT 531_ AFSFL 536_ RDHLR 541_ CLHVK 546_ FTDVA 551_ EIPAW 556_ VYLLK 561_ NLREL 566_ YLIGN 571_ LNSEN 576_ NKMIG 581_ LESLR 586_ ELRHL 591_ KILHV 596_ KSNLT 601_ KVPSN 606_ ITDVA 611_ PHLTK 616_ LVIHN 621_ DGTKL 626_ LVLNS 631_ LKKMM 636_ NVAEL 641_ ELQNC 646_ ELERI 651_ PHAIF 656_ SLSNL 661_ QELDL 666_ KSNNI 671_ RTIEE 676_ IISFQ 681_ HLKRL 686_ TCLKL 691_ WHNKI 696_ VTIPP 701_ SITHV 706_ KNLES 711_ LYFSN 716_ NKLES 721_ LPVAV 726_ FSLQK 731_ LRCLD 736_ VSYNN 741_ ISMIP 746_ IEIGL 751_ LQNLQ 756_ HLHIT 761_ GNKVD 766_ ILPKQ 771_ LFKCI 776_ KLRTL 781_ NLGQN 786_ CITSL 791_ PEKVG 796_ QLSQL 801_ TQLEL 806_ KGNCL 811_ DRLPA 816_ QLGQC 821_ RMLKK 826_ SGLVV 831_ EDHLF 836_ DTLPL 841_ EVKEA 846_ LNQDI 851_NIPFA
1: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309)