Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain]
1_MNPIV 6_ VVHGG 11_ GAGPI 16_ SKDRK 21_ ERVHQ 26_ GMVRA 31_ ATVGY 36_ GILRE 41_ GGSAV 46_ DAVEG 51_ AVVAL 56_ EDDPE 61_ FNAGC 66_ GSVLN 71_ TNGEV 76_ EMDAS 81_ IMDGK 86_ DLSAG 91_ AVSAV 96_ QCIAN 101_ PIKLA 106_ RLVME 111_ KTPHC 116_ FLTDQ 121_ GAAQF 126_ AAAMG 131_ VPEIP 136_ GEKLV 141_ TERNK 146_ KRLEK 151_ EKHEK 156_ GAQKT 161_ DCQKN 166_ LGTVG 171_ AVALD 176_ CKGNV 181_ AYATS 186_ TGGIV 191_ NKMVG 196_ RVGDS 201_ PCLGA 206_ GGYAD 211_ NDIGA 216_ VSTTG 221_ HGESI 226_ LKVNL 231_ ARLTL 236_ FHIEQ 241_ GKTVE 246_ EAADL 251_ SLGYM 256_ KSRVK 261_ GLGGL 266_ IVVSK 271_ TGDWV 276_ AKWTS 281_ TSMPW 286_ AAAKD 291_ GKLHF 296_ GIDPD 301_DTTIT
1: Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine