Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1)
1_MPNTA 6_ MKKKV 11_ LLMGK 16_ SGSGK 21_ TSMRS 26_ IIFAN 31_ YIARD 36_ TRRLG 41_ ATIDV 46_ EHSHV 51_ RFLGN 56_ LVLNL 61_ WDCGG 66_ QDTFM 71_ ENYFT 76_ SQRDN 81_ IFRNV 86_ EVLIY 91_ VFDVE 96_ SRELE 101_ KDMHY 106_ YQSCL 111_ EAILQ 116_ NSPDA 121_ KIFCL 126_ VHKMD 131_ LVQED 136_ QRDLI 141_ FKERE 146_ EDLRR 151_ LSRPL 156_ ECACF 161_ RTSIW 166_ DETLY 171_ KAWSS 176_ IVYQL 181_ IPNVQ 186_ QLEMN 191_ LRNFA 196_ QIIEA 201_ DEVLL 206_ FERAT 211_ FLVIS 216_ HYQCK 221_ EQRDV 226_ HRFEK 231_ ISNII 236_ KQFKL 241_ SCSKL 246_ AASFQ 251_ SMEVR 256_ NSNFA 261_ AFIDI 266_ FTSNT 271_ YVMVV 276_ MSDPS 281_ IPSAA 286_ TLINI 291_ RNARK 296_ HFEKL 301_ ERVDG 306_PKHSL
1: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:25936802, PubMed:31601708, PubMed:31601764, PubMed:38103557). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:20381137, PubMed:24095279, PubMed:25936802, PubMed:31601708, PubMed:31601764, PubMed:32868926). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:25936802, PubMed:31601708, PubMed:31601764). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (PubMed:8995684)
2: (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death