Docking protein 3 (Downstream of tyrosine kinase 3)
1_MTRGA 6_ RLRSD 11_ ARAQL 16_ NQLSL 21_ DGGTG 26_ SGQKG 31_ KCEEF 36_ PSSLS 41_ SVSPG 46_ LEAAA 51_ LLLAV 56_ TMDPL 61_ ETPIK 66_ DGILY 71_ QQHVK 76_ FGKKC 81_ WRKVW 86_ ALLYA 91_ GGPSG 96_ VARLE 101_ SWEVR 106_ DGGLG 111_ AAGDR 116_ SAGPG 121_ RRGER 126_ RVIRL 131_ ADCVS 136_ VLPAD 141_ GESCP 146_ RDTGA 151_ FLLTT 156_ TERSH 161_ LLAAQ 166_ HRQAW 171_ MGPIC 176_ QLAFP 181_ GTGEA 186_ SSGST 191_ DAQSP 196_ KRGLV 201_ PMEEN 206_ SIYSS 211_ WQEVG 216_ EFPVV 221_ VQRTE 226_ AATRC 231_ QLKGP 236_ ALLVL 241_ GPDAI 246_ QLREA 251_ KGTQA 256_ LYSWP 261_ YHFLR 266_ KFGSD 271_ KGVFS 276_ FEAGR 281_ RCHSG 286_ EGLFA 291_ FSTPC 296_ APDLC 301_ RAVAG 306_ AIARQ 311_ RERLP 316_ ELTRP 321_ QPCPL 326_ PRATS 331_ LPSLD 336_ TPGEL 341_ REMPP 346_ GPEPP 351_ TSRKM 356_ HLAEP 361_ GPQSL 366_ PLLLG 371_ PEPND 376_ LASGL 381_ YASVC 386_ KRASG 391_ PPGNE 396_ HLYEN 401_ LCVLE 406_ ASPTL 411_ HGGEP 416_ EPHEG 421_ PGSRS 426_ PTTSP 431_ IYHNG 436_ QDLSW 441_ PGPAN 446_ DSTLE 451_ AQYRR 456_ LLELD 461_ QVEGT 466_ GRPDP 471_ QAGFK 476_ AKLVT 481_ LLSRE 486_ RRKGP 491_APCDR
1: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)