Fatty acid 2-hydroxylase (EC 1.14.18.-) (Fatty acid alpha-hydroxylase) (Fatty acid hydroxylase domain-containing protein 1)
1_MAPAP 6_ PPAAS 11_ FSPSE 16_ VQRRL 21_ AAGAC 26_ WVRRG 31_ ARLYD 36_ LSSFV 41_ RHHPG 46_ GEQLL 51_ RARAG 56_ QDISA 61_ DLDGP 66_ PHRHS 71_ ANARR 76_ WLEQY 81_ YVGEL 86_ RGEQQ 91_ GSMEN 96_ EPVAL 101_ EETQK 106_ TDPAM 111_ EPRFK 116_ VVDWD 121_ KDLVD 126_ WRKPL 131_ LWQVG 136_ HLGEK 141_ YDEWV 146_ HQPVT 151_ RPIRL 156_ FHSDL 161_ IEGLS 166_ KTVWY 171_ SVPII 176_ WVPLV 181_ LYLSW 186_ SYYRT 191_ FAQGN 196_ VRLFT 201_ SFTTE 206_ YTVAV 211_ PKSMF 216_ PGLFM 221_ LGTFL 226_ WSLIE 231_ YLIHR 236_ FLFHM 241_ KPPSD 246_ SYYLI 251_ MLHFV 256_ MHGQH 261_ HKAPF 266_ DGSRL 271_ VFPPV 276_ PASLV 281_ IGVFY 286_ LCMQL 291_ ILPEA 296_ VGGTV 301_ FAGGL 306_ LGYVL 311_ YDMTH 316_ YYLHF 321_ GSPHK 326_ GSYLY 331_ SLKAH 336_ HVKHH 341_ FAHQK 346_ SGFGI 351_ STKLW 356_ DYCFH 361_ TLTPE 366_KPHLK
1: Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity)