Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35)
1_MAAAA 6_ AMAEQ 11_ ESARN 16_ GGRNR 21_ GGVQR 26_ VEGKL 31_ RASVE 36_ KGDYY 41_ EAHQM 46_ YRTLF 51_ FRYMS 56_ QSKHT 61_ EAREL 66_ MYSGA 71_ LLFFS 76_ HGQQN 81_ SAADL 86_ SMLVL 91_ ESLEK 96_ AEVEV 101_ ADELL 106_ ENLAK 111_ VFSLM 116_ DPNSP 121_ ERVTF 126_ VSRAL 131_ KWSSG 136_ GSGKL 141_ GHPRL 146_ HQLLA 151_ LTLWK 156_ EQNYC 161_ ESRYH 166_ FLHSA 171_ DGEGC 176_ ANMLV 181_ EYSTS 186_ RGFRS 191_ EVDMF 196_ VAQAV 201_ LQFLC 206_ LKNKS 211_ SASVV 216_ FTTYT 221_ QKHPS 226_ IEDGP 231_ PFVEP 236_ LLNFI 241_ WFLLL 246_ AVDGG 251_ KLTVF 256_ TVLCE 261_ QYQPS 266_ LRRDP 271_ MYNEY 276_ LDRIG 281_ QLFFG 286_ VPPKQ 291_ TSSYG 296_ GLLGN 301_ LLTSL 306_ MGSSE 311_ QEDGE 316_ ESPSD 321_GSPIE
1: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303)