COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
1_MAAAA 6_ AAAAA 11_ TNGTG 16_ GSSGM 21_ EVDAA 26_ VVPSV 31_ MACGV 36_ TGSVS 41_ VALHP 46_ LVILN 51_ ISDHW 56_ IRMRS 61_ QEGRP 66_ VQVIG 71_ ALIGK 76_ QEGRN 81_ IEVMN 86_ SFELL 91_ SHTVE 96_ EKIII 101_ DKEYY 106_ YTKEE 111_ QFKQV 116_ FKELE 121_ FLGWY 126_ TTGGP 131_ PDPSD 136_ IHVHK 141_ QVCEI 146_ IESPL 151_ FLKLN 156_ PMTKH 161_ TDLPV 166_ SVFES 171_ VIDII 176_ NGEAT 181_ MLFAE 186_ LTYTL 191_ ATEEA 196_ ERIGV 201_ DHVAR 206_ MTATG 211_ SGENS 216_ TVAEH 221_ LIAQH 226_ SAIKM 231_ LHSRV 236_ KLILE 241_ YVKAS 246_ EAGEV 251_ PFNHE 256_ ILREA 261_ YALCH 266_ CLPVL 271_ STDKF 276_ KTDFY 281_ DQCND 286_ VGLMA 291_ YLGTI 296_ TKTCN 301_ TMNQF 306_ VNKFN 311_ VLYDR 316_ QGIGR 321_RMRGL
1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets