Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1)
1_MPSTN 6_ RAGSL 11_ KDPEI 16_ AELFF 21_ KEDPE 26_ KLFTD 31_ LREIG 36_ HGSFG 41_ AVYFA 46_ RDVRT 51_ NEVVA 56_ IKKMS 61_ YSGKQ 66_ STEKW 71_ QDIIK 76_ EVKFL 81_ QRIKH 86_ PNSIE 91_ YKGCY 96_ LREHT 101_ AWLVM 106_ EYCLG 111_ SASDL 116_ LEVHK 121_ KPLQE 126_ VEIAA 131_ ITHGA 136_ LQGLA 141_ YLHSH 146_ TMIHR 151_ DIKAG 156_ NILLT 161_ EPGQV 166_ KLADF 171_ GSASM 176_ ASPAN 181_ SFVGT 186_ PYWMA 191_ PEVIL 196_ AMDEG 201_ QYDGK 206_ VDVWS 211_ LGITC 216_ IELAE 221_ RKPPL 226_ FNMNA 231_ MSALY 236_ HIAQN 241_ ESPTL 246_ QSNEW 251_ SDYFR 256_ NFVDS 261_ CLQKI 266_ PQDRP 271_ TSEEL 276_ LKHIF 281_ VLRER 286_ PETVL 291_ IDLIQ 296_ RTKDA 301_ VRELD 306_ NLQYR 311_ KMKKL 316_ LFQEA 321_ HNGPA 326_ VEAQE 331_ EEEEQ 336_ DHGVG 341_ RTGTV 346_ NSVGS 351_ NQSIP 356_ SMSIS 361_ ASSQS 366_ SSVNS 371_ LPDVS 376_ DDKSE 381_ LDMME 386_ GDHTV 391_ MSNSS 396_ VIHLK 401_ PEEEN 406_ YREEG 411_ DPRTR 416_ ASDPQ 421_ SPPQV 426_ SRHKS 431_ HYRNR 436_ EHFAT 441_ IRTAS 446_ LVTRQ 451_ MQEHE 456_ QDSEL 461_ REQMS 466_ GYKRM 471_ RRQHQ 476_ KQLMT 481_ LENKL 486_ KAEMD 491_ EHRLR 496_ LDKDL 501_ ETQRN 506_ NFAAE 511_ MEKLI 516_ KKHQA 521_ AMEKE 526_ AKVMS 531_ NEEKK 536_ FQQHI 541_ QAQQK 546_ KELNS 551_ FLESQ 556_ KREYK 561_ LRKEQ 566_ LKEEL 571_ NENQS 576_ TPKKE 581_ KQEWL 586_ SKQKE 591_ NIQHF 596_ QAEEE 601_ ANLLR 606_ RQRQY 611_ LELEC 616_ RRFKR 621_ RMLLG 626_ RHNLE 631_ QDLVR 636_ EELNK 641_ RQTQK 646_ DLEHA 651_ MLLRQ 656_ HESMQ 661_ ELEFR 666_ HLNTI 671_ QKMRC 676_ ELIRL 681_ QHQTE 686_ LTNQL 691_ EYNKR 696_ REREL 701_ RRKHV 706_ MEVRQ 711_ QPKSL 716_ KSKEL 721_ QIKKQ 726_ FQDTC 731_ KIQTR 736_ QYKAL 741_ RNHLL 746_ ETTPK 751_ SEHKA 756_ VLKRL 761_ KEEQT 766_ RKLAI 771_ LAEQY 776_ DHSIN 781_ EMLST 786_ QALRL 791_ DEAQE 796_ AECQV 801_ LKMQL 806_ QQELE 811_ LLNAY 816_ QSKIK 821_ MQAEA 826_ QHDRE 831_ LRELE 836_ QRVSL 841_ RRALL 846_ EQKIE 851_ EEMLA 856_ LQNER 861_ TERIR 866_ SLLER 871_ QAREI 876_ EAFDS 881_ ESMRL 886_ GFSNM 891_ VLSNL 896_ SPEAF 901_ SHSYP 906_ GASGW 911_ SHNPT 916_ GGPGP 921_ HWGHP 926_ MGGPP 931_ QAWGH 936_ PMQGG 941_ PQPWG 946_ HPSGP 951_ MQGVP 956_ RGSSM 961_ GVRNS 966_ PQALR 971_ RTASG 976_ GRTEQ 981_ GMSRS 986_ TSVTS 991_ QISNG 996_SHMSY
1: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity)