Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11)
1_MMLSE 6_ QAQKW 11_ FPTHV 16_ QVTVL 21_ QAKDL 26_ KPKGK 31_ SGTND 36_ TYTII 41_ QLGKE 46_ KYSTS 51_ VAEKT 56_ LEPVW 61_ KEEAS 66_ FELPG 71_ LLIQG 76_ SPEKY 81_ ILFLI 86_ VMHRS 91_ LVGLD 96_ KFLGQ 101_ VAINL 106_ NDIFE 111_ DKQRR 116_ KTEWF 121_ RLESK 126_ QGKRI 131_ KNRGE 136_ IKVNI 141_ QFMRN 146_ NMTAS 151_ MFDLS 156_ MKDKT 161_ RSPFA 166_ KLKDK 171_ MKGRK 176_ NDGTF 181_ SDTSS 186_ AIIPS 191_ THMPD 196_ ANSEF 201_ SSGEI 206_ QMKSK 211_ PKKPF 216_ LLGPQ 221_ RLSSA 226_ HSMSD 231_ LSGSH 236_ MSSEK 241_ LKAGT 246_ IGQTH 251_ LLGHQ 256_ LDSFG 261_ TVPES 266_ GSLKS 271_ PHRRT 276_ LSFDT 281_ SKMNQ 286_ PDSIV 291_ DEGEL 296_ CFGRQ 301_ NDPFT 306_ NVTAS 311_ LPQKF 316_ ATLPR 321_ KKNPF 326_ EESSE 331_ TWDSS 336_ MNLFS 341_ KPIEI 346_ RKENK 351_ REKRE 356_ KVSLF 361_ ERVTG 366_ KKDSR 371_ RSDKL 376_ NNGGS 381_ DSPCD 386_ LKSPN 391_ AFSEN 396_ RQDYF 401_ DYEST 406_ NPFTA 411_ KFRAS 416_ NIMPS 421_ SSFHM 426_ SPTSN 431_ EDLRK 436_ IPDSN 441_ PFDAT 446_ AGYRS 451_ LTYEE 456_ VLQEL 461_ VKHKE 466_ LLRRK 471_ DTHIR 476_ ELEDY 481_ IDNLL 486_ VRVME 491_ ETPSI 496_ LRVPY 501_ EPSRK 506_AGKFS
1: A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics