Tubulinyl-Tyr carboxypeptidase 1 (EC 3.4.17.17) (Tubulin carboxypeptidase 1) (Tyrosine carboxypeptidase 1) (TTCP 1) (Vasohibin-1)
1_MPGGK 6_ KVAGG 11_ GSSGA 16_ TPTSA 21_ AATAP 26_ SGVRR 31_ LETSE 36_ GTSAQ 41_ RDEEP 46_ EEEGE 51_ EDLRD 56_ GGVPF 61_ FVNRG 66_ GLPVD 71_ EATWE 76_ RMWKH 81_ VAKIH 86_ PDGEK 91_ VAQRI 96_ RGATD 101_ LPKIP 106_ IPSVP 111_ TFQPS 116_ TPVPE 121_ RLEAV 126_ QRYIR 131_ ELQYN 136_ HTGTQ 141_ FFEIK 146_ KSRPL 151_ TGLMD 156_ LAKEM 161_ TKEAL 166_ PIKCL 171_ EAVIL 176_ GIYLT 181_ NSMPT 186_ LERFP 191_ ISFKT 196_ YFSGN 201_ YFRHI 206_ VLGVN 211_ FAGRY 216_ GALGM 221_ SRRED 226_ LMYKP 231_ PAFRT 236_ LSELV 241_ LDFEA 246_ AYGRC 251_ WHVLK 256_ KVKLG 261_ QSVSH 266_ DPHSV 271_ EQIEW 276_ KHSVL 281_ DVERL 286_ GRDDF 291_ RKELE 296_ RHARD 301_ MRLKI 306_ GKGTG 311_ PPSPT 316_ KDRKK 321_ DVSSP 326_ QRAQS 331_ SPHRR 336_ NSRSE 341_ RRPSG 346_ DKKTS 351_ EPKAM 356_PDLNG
1: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869, PubMed:31171830, PubMed:31235910, PubMed:31235911, PubMed:31270470). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096)