Diphthine--ammonia ligase (EC 6.3.1.14) (ATP-binding domain-containing protein 4) (Diphthamide synthase) (Diphthamide synthetase) (Protein DPH6 homolog)
1_MRVAA 6_ LISGG 11_ KDSCY 16_ NMMQC 21_ IAAGH 26_ QIVAL 31_ ANLRP 36_ AENQV 41_ GSDEL 46_ DSYMY 51_ QTVGH 56_ HAIDL 61_ YAEAM 66_ ALPLY 71_ RRTIR 76_ GRSLD 81_ TRQVY 86_ TKCEG 91_ DEVED 96_ LYELL 101_ KLVKE 106_ KEEVE 111_ GISVG 116_ AILSD 121_ YQRIR 126_ VENVC 131_ KRLNL 136_ QPLAY 141_ LWQRN 146_ QEDLL 151_ REMIS 156_ SNIQA 161_ MIIKV 166_ AALGL 171_ DPDKH 176_ LGKTL 181_ DQMEP 186_ YLIEL 191_ SKKYG 196_ VHVCG 201_ EGGEY 206_ ETFTL 211_ DCPLF 216_ KKKII 221_ VDSSE 226_ VVIHS 231_ ADAFA 236_ PVAYL 241_ RFLEL 246_ HLEDK 251_ VSSVP 256_ DNYRT 261_SNYIY
1: Amidase that may catalyze the last step of diphthamide biosynthesis using ammonium and ATP (PubMed:23169644). Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity)