MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A)
1_MSFLF 6_ GSRSS 11_ KTFKP 16_ KKNIP 21_ EGSHQ 26_ YELLK 31_ HAEAT 36_ LGSGN 41_ LRMAV 46_ MLPEG 51_ EDLNE 56_ WVAVN 61_ TVDFF 66_ NQINM 71_ LYGTI 76_ TDFCT 81_ EESCP 86_ VMSAG 91_ PKYEY 96_ HWADG 101_ TNIKK 106_ PIKCS 111_ APKYI 116_ DYLMT 121_ WVQDQ 126_ LDDET 131_ LFPSK 136_ IGVPF 141_ PKNFM 146_ SVAKT 151_ ILKRL 156_ FRVYA 161_ HIYHQ 166_ HFDPV 171_ IQLQE 176_ EAHLN 181_ TSFKH 186_ FIFFV 191_ QEFNL 196_ IDRRE 201_ LAPLQ 206_ ELIEK 211_LTSKD
1: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L