Charged multivesicular body protein 1b (CHMP1.5) (Chromatin-modifying protein 1b) (CHMP1b) (Vacuolar protein sorting-associated protein 46-2) (Vps46-2) (hVps46-2)
1_MSNME 6_ KHLFN 11_ LKFAA 16_ KELSR 21_ SAKKC 26_ DKEEK 31_ AEKAK 36_ IKKAI 41_ QKGNM 46_ EVARI 51_ HAENA 56_ IRQKN 61_ QAVNF 66_ LRMSA 71_ RVDAV 76_ AARVQ 81_ TAVTM 86_ GKVTK 91_ SMAGV 96_ VKSMD 101_ ATLKT 106_ MNLEK 111_ ISALM 116_ DKFEH 121_ QFETL 126_ DVQTQ 131_ QMEDT 136_ MSSTT 141_ TLTTP 146_ QNQVD 151_ MLLQE 156_ MADEA 161_ GLDLN 166_ MELPQ 171_ GQTGS 176_ VGTSV 181_ ASAEQ 186_ DELSQ 191_RLARL
1: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release