RAS guanyl-releasing protein 2 (Calcium and DAG-regulated guanine nucleotide exchange factor I) (CalDAG-GEFI) (Cdc25-like protein) (hCDC25L) (F25B3.3 kinase-like protein)
1_MAGTL 6_ DLDKG 11_ CTVEE 16_ LLRGC 21_ IEAFD 26_ DSGKV 31_ RDPQL 36_ VRMFL 41_ MMHPW 46_ YIPSS 51_ QLAAK 56_ LLHIY 61_ QQSRK 66_ DNSNS 71_ LQVKT 76_ CHLVR 81_ YWISA 86_ FPAEF 91_ DLNPE 96_ LAEQI 101_ KELKA 106_ LLDQE 111_ GNRRH 116_ SSLID 121_ IDSVP 126_ TYKWK 131_ RQVTQ 136_ RNPVG 141_ QKKRK 146_ MSLLF 151_ DHLEP 156_ MELAE 161_ HLTYL 166_ EYRSF 171_ CKILF 176_ QDYHS 181_ FVTHG 186_ CTVDN 191_ PVLER 196_ FISLF 201_ NSVSQ 206_ WVQLM 211_ ILSKP 216_ TAPQR 221_ ALVIT 226_ HFVHV 231_ AEKLL 236_ QLQNF 241_ NTLMA 246_ VVGGL 251_ SHSSI 256_ SRLKE 261_ THSHV 266_ SPETI 271_ KLWEG 276_ LTELV 281_ TATGN 286_ YGNYR 291_ RRLAA 296_ CVGFR 301_ FPILG 306_ VHLKD 311_ LVALQ 316_ LALPD 321_ WLDPA 326_ RTRLN 331_ GAKMK 336_ QLFSI 341_ LEELA 346_ MVTSL 351_ RPPVQ 356_ ANPDL 361_ LSLLT 366_ VSLDQ 371_ YQTED 376_ ELYQL 381_ SLQRE 386_ PRSKS 391_ SPTSP 396_ TSCTP 401_ PPRPP 406_ VLEEW 411_ TSAAK 416_ PKLDQ 421_ ALVVE 426_ HIEKM 431_ VESVF 436_ RNFDV 441_ DGDGH 446_ ISQEE 451_ FQIIR 456_ GNFPY 461_ LSAFG 466_ DLDQN 471_ QDGCI 476_ SREEM 481_ VSYFL 486_ RSSSV 491_ LGGRM 496_ GFVHN 501_ FQESN 506_ SLRPV 511_ ACRHC 516_ KALIL 521_ GIYKQ 526_ GLKCR 531_ ACGVN 536_ CHKQC 541_ KDRLS 546_ VECRR 551_ RAQSV 556_ SLEGS 561_ APSPS 566_ PMHSH 571_ HHRAF 576_ SFSLP 581_ RPGRR 586_ GSRPP 591_ EIREE 596_ EVQTV 601_EDGVF
1: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activate other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway