CXXC-type zinc finger protein 5 (CF5) (Putative MAPK-activating protein PM08) (Putative NF-kappa-B-activating protein 102) (Retinoid-inducible nuclear factor) (RINF)
1_MSSLG 6_ GGSQD 11_ AGGSS 16_ SSSTN 21_ GSGGS 26_ GSSGP 31_ KAGAA 36_ DKSAV 41_ VAAAA 46_ PASVA 51_ DDTPP 56_ PERRN 61_ KSGII 66_ SEPLN 71_ KSLRR 76_ SRPLS 81_ HYSSF 86_ GSSGG 91_ SGGGS 96_ MMGGE 101_ SADKA 106_ TAAAA 111_ AASLL 116_ ANGHD 121_ LAAAM 126_ AVDKS 131_ NPTSK 136_ HKSGA 141_ VASLL 146_ SKAER 151_ ATELA 156_ AEGQL 161_ TLQQF 166_ AQSTE 171_ MLKRV 176_ VQEHL 181_ PLMSE 186_ AGAGL 191_ PDMEA 196_ VAGAE 201_ ALNGQ 206_ SDFPY 211_ LGAFP 216_ INPGL 221_ FIMTP 226_ AGVFL 231_ AESAL 236_ HMAGL 241_ AEYPM 246_ QGELA 251_ SAISS 256_ GKKKR 261_ KRCGM 266_ CAPCR 271_ RRINC 276_ EQCSS 281_ CRNRK 286_ TGHQI 291_ CKFRK 296_ CEELK 301_ KKPSA 306_ ALEKV 311_ MLPTG 316_AAFRW
1: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034)