Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
1_MGDPE 6_ RPEAA 11_ GLDQD 16_ ERSSS 21_ DTNES 26_ EIKSN 31_ EEPLL 36_ RKSSR 41_ RFVIF 46_ PIQYP 51_ DIWKM 56_ YKQAQ 61_ ASFWT 66_ AEEVD 71_ LSKDL 76_ PHWNK 81_ LKADE 86_ KYFIS 91_ HILAF 96_ FAASD 101_ GIVNE 106_ NLVER 111_ FSQEV 116_ QVPEA 121_ RCFYG 126_ FQILI 131_ ENVHS 136_ EMYSL 141_ LIDTY 146_ IRDPK 151_ KREFL 156_ FNAIE 161_ TMPYV 166_ KKKAD 171_ WALRW 176_ IADRK 181_ STFGE 186_ RVVAF 191_ AAVEG 196_ VFFSG 201_ SFAAI 206_ FWLKK 211_ RGLMP 216_ GLTFS 221_ NELIS 226_ RDEGL 231_ HCDFA 236_ CLMFQ 241_ YLVNK 246_ PSEER 251_ VREII 256_ VDAVK 261_ IEQEF 266_ LTEAL 271_ PVGLI 276_ GMNCI 281_ LMKQY 286_ IEFVA 291_ DRLLV 296_ ELGFS 301_ KVFQA 306_ ENPFD 311_ FMENI 316_ SLEGK 321_ TNFFE 326_ KRVSE 331_ YQRFA 336_ VMAET 341_ TDNVF 346_TLDAD
1: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage