Heparan sulfate 2-O-sulfotransferase 1 (2-O-sulfotransferase) (2OST) (EC 2.8.2.-)
1_MGLLR 6_ IMMPP 11_ KLQLL 16_ AVVAF 21_ AVAML 26_ FLENQ 31_ IQKLE 36_ ESRSK 41_ LERAI 46_ ARHEV 51_ REIEQ 56_ RHTMD 61_ GPRQD 66_ ATLDE 71_ EEDMV 76_ IIYNR 81_ VPKTA 86_ STSFT 91_ NIAYD 96_ LCAKN 101_ KYHVL 106_ HINTT 111_ KNNPV 116_ MSLQD 121_ QVRFV 126_ KNITS 131_ WKEMK 136_ PGFYH 141_ GHVSY 146_ LDFAK 151_ FGVKK 156_ KPIYI 161_ NVIRD 166_ PIERL 171_ VSYYY 176_ FLRFG 181_ DDYRP 186_ GLRRR 191_ KQGDK 196_ KTFDE 201_ CVAEG 206_ GSDCA 211_ PEKLW 216_ LQIPF 221_ FCGHS 226_ SECWN 231_ VGSRW 236_ AMDQA 241_ KYNLI 246_ NEYFL 251_ VGVTE 256_ ELEDF 261_ IMLLE 266_ AALPR 271_ FFRGA 276_ TELYR 281_ TGKKS 286_ HLRKT 291_ TEKKL 296_ PTKQT 301_ IAKLQ 306_ QSDIW 311_ KMENE 316_ FYEFA 321_ LEQFQ 326_ FIRAH 331_ AVREK 336_ DGDLY 341_ ILAQN 346_ FFYEK 351_IYPKS
1: Catalyzes the transfer of a sulfo group from 3'-phospho-5'-adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis (By similarity). Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme (By similarity)