STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96)
1_MSFLV 6_ SKPER 11_ IRRWV 16_ SEKFI 21_ VEGLR 26_ DLELF 31_ GEQPP 36_ GDTRR 41_ KTNDA 46_ SSESI 51_ ASFSK 56_ QEVMS 61_ SFLPE 66_ GGCYE 71_ LLTVI 76_ GKGFE 81_ DLMTV 86_ NLARY 91_ KPTGE 96_ YVTVR 101_ RINLE 106_ ACSNE 111_ MVTFL 116_ QGELH 121_ VSKLF 126_ NHPNI 131_ VPYRA 136_ TFIAD 141_ NELWV 146_ VTSFM 151_ AYGSA 156_ KDLIC 161_ THFMD 166_ GMNEL 171_ AIAYI 176_ LQGVL 181_ KALDY 186_ IHHMG 191_ YVHRS 196_ VKASH 201_ ILISV 206_ DGKVY 211_ LSGLR 216_ SNLSM 221_ ISHGQ 226_ RQRVV 231_ HDFPK 236_ YSVKV 241_ LPWLS 246_ PEVLQ 251_ QNLQG 256_ YDAKS 261_ DIYSV 266_ GITAC 271_ ELANG 276_ HVPFK 281_ DMPAT 286_ QMLLE 291_ KLNGT 296_ VPCLL 301_ DTSTI 306_ PAEEL 311_ TMSPS 316_ RSVAN 321_ SGLSD 326_ SLTTS 331_ TPRPS 336_ NGDSP 341_ SHPYH 346_ RTFSP 351_ HFHHF 356_ VEQCL 361_ QRNPD 366_ ARPSA 371_ STLLN 376_ HSFFK 381_ QIKRR 386_ ASEAL 391_ PELLR 396_ PVTPI 401_ TNFEG 406_ SQSQD 411_ HSGIF 416_ GLVTN 421_ LEELE 426_VDDWE
1: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation