[F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3)
1_MEERK 6_ HETMN 11_ PAHVL 16_ FDRFV 21_ QATTC 26_ KGTLK 31_ AFQEL 36_ CDHLE 41_ LKPKD 46_ YRSFY 51_ HKLKS 56_ KLNYW 61_ KAKAL 66_ WAKLD 71_ KRGSH 76_ KDYKK 81_ GKACT 86_ NTKCL 91_ IIGAG 96_ PCGLR 101_ TAIDL 106_ SLLGA 111_ KVVVI 116_ EKRDA 121_ FSRNN 126_ VLHLW 131_ PFTIH 136_ DLRGL 141_ GAKKF 146_ YGKFC 151_ AGAID 156_ HISIR 161_ QLQLI 166_ LLKVA 171_ LILGI 176_ EIHVN 181_ VEFQG 186_ LIQPP 191_ EDQEN 196_ ERIGW 201_ RALVH 206_ PKTHP 211_ VSEYE 216_ FEVII 221_ GGDGR 226_ RNTLE 231_ GFRRK 236_ EFRGK 241_ LAIAI 246_ TANFI 251_ NRNTT 256_ AEAKV 261_ EEISG 266_ VAFIF 271_ NQKFF 276_ QELRE 281_ ATGID 286_ LENIV 291_ YYKDD 296_ THYFV 301_ MTAKK 306_ QSLLD 311_ KGVIL 316_ HDYAD 321_ TELLL 326_ SRENV 331_ DQEAL 336_ LSYAR 341_ EAADF 346_ STQQQ 351_ LPSLD 356_ FAINH 361_ YGQPD 366_ VAMFD 371_ FTCMY 376_ ASENA 381_ ALVRE 386_ QNGHQ 391_ LLVAL 396_ VGDSL 401_ LEPFW 406_ PMGTG 411_ IARGF 416_ LAAMD 421_ SAWMV 426_ RSWSL 431_ GTSPL 436_ EVLAE 441_ RESIY 446_ RLLPQ 451_ TTPEN 456_ VSKNF 461_ SQYSI 466_ DPVTR 471_ YPNIN 476_ VNFLR 481_ PSQVR 486_ HLYDT 491_ GETKD 496_ IHLEM 501_ ESLVN 506_ SRTTP 511_ KLTRN 516_ ESVAR 521_ SSKLL 526_ GWCQR 531_ QTDGY 536_ AGVNV 541_ TDLTM 546_ SWKSG 551_ LALCA 556_ IIHRY 561_ RPDLI 566_ DFDSL 571_ DEQNV 576_ EKNNQ 581_ LAFDI 586_ AEKEL 591_ GISPI 596_ MTGKE 601_ MASVG 606_ EPDKL 611_ SMVMY 616_ LTQFY 621_ EMFKD 626_ SLPSS 631_ DTLDL 636_ NAEEK 641_ AVLIA 646_ STRSP 651_ ISFLS 656_ KLGQT 661_ ISRKR 666_ SPKDK 671_ KEKDL 676_ DGAGK 681_ RRKTS 686_ QSEEE 691_ EAPRG 696_ HRGER 701_ PTLVS 706_ TLTDR 711_ RMDVA 716_ VGNQN 721_ KVKYM 726_ ATQLL 731_ AKFEE 736_ NAPAQ 741_ SIGIR 746_ RQGSM 751_ KKEFP 756_ QNLGG 761_ SDTCY 766_ FCQKR 771_ VYVME 776_ RLSAE 781_ GKFFH 786_ RSCFK 791_ CEYCA 796_ TTLRL 801_ SAYAY 806_ DIEDG 811_ KFYCK 816_ PHYCY 821_ RLSGY 826_ AQRKR 831_ PAVAP 836_ LSGKE 841_ AKGPL 846_ QDGAT 851_ TDANG 856_ RANAV 861_ ASSTE 866_ RTPGS 871_ GVNGL 876_ EEPSI 881_ AKRLR 886_ GTPER 891_ IELEN 896_ YRLSL 901_ RQAEA 906_ LQEVP 911_ EETQA 916_ EHNLS 921_ SVLDT 926_ GAEED 931_ VASSS 936_ SESEM 941_ EEEGE 946_ EEEEE 951_ PRLPP 956_ SDLGG 961_ VPWKE 966_ AVRIH 971_ ALLKG 976_ KSEEE 981_ LEASK 986_ SFGPG 991_ NEEEE 996_ EEEEE 1001_ YEEEE 1006_ EEDYD 1011_ EEEEE 1016_ SSEAG 1021_ NQRLQ 1026_ QVMHA 1031_ ADPLE 1036_ IQADV 1041_ HWTHI 1046_ REREE 1051_ EERMA 1056_ PASES 1061_ SASGA 1066_ PLDEN 1071_ DLEED 1076_ VDSEP 1081_ AEIEG 1086_ EAAED 1091_ GDPGD 1096_ TGAEL 1101_ DDDQH 1106_ WSDSP 1111_ SDADR 1116_ ELRLP 1121_ CPAEG 1126_ EAELE 1131_ LRVSE 1136_ DEEKL 1141_ PASPK 1146_ HQERG 1151_ PSQAT 1156_ SPIRS 1161_ PQESA 1166_ LLFIP 1171_ VHSPS 1176_ TEGPQ 1181_ LPPVP 1186_ AATQE 1191_ KSPEE 1196_ RLFPE 1201_ PLLPK 1206_ EKPKA 1211_ DAPSD 1216_ LKAVH 1221_ SPIRS 1226_ QPVTL 1231_ PEART 1236_ PVSPG 1241_ SPQPQ 1246_ PPVAA 1251_ STPPP 1256_ SPLPI 1261_ CSQPQ 1266_ PSTEA 1271_ TVPSP 1276_ TQSPI 1281_ RFQPA 1286_ PAKTS 1291_ TPLAP 1296_ LPVQS 1301_ QSDTK 1306_ DRLGS 1311_ PLAVD 1316_ EALRR 1321_ SDLVE 1326_ EFWMK 1331_ SAEIR 1336_ RSLGL 1341_ TPVDR 1346_ SKGPE 1351_ PSFPT 1356_ PAFRP 1361_ VSLKS 1366_ YSVEK 1371_ SPQDE 1376_ GLHLL 1381_ KPLSI 1386_ PKRLG 1391_ LPKPE 1396_ GEPLS 1401_ LPTPR 1406_ SPSDR 1411_ ELRSA 1416_ QEERR 1421_ ELSSS 1426_ SGLGL 1431_ HGSSS 1436_ NMKTL 1441_ GSQSF 1446_ NTSDS 1451_ AMLTP 1456_ PSSPP 1461_ PPPPP 1466_ GEEPA 1471_ TLRRK 1476_ LREAE 1481_ PNASV 1486_ VPPPL 1491_ PATWM 1496_ RPPRE 1501_ PAQPP 1506_ REEVR 1511_ KSFVE 1516_ SVEEI 1521_ PFADD 1526_ VEDTY 1531_ DDKTE 1536_ DSSLQ 1541_ EKFFT 1546_ PPSCW 1551_ PRPEK 1556_ PRHPP 1561_ LAKEN 1566_ GRLPA 1571_ LEGTL 1576_ QPQKR 1581_ GLPLV 1586_ SAEAK 1591_ ELAEE 1596_ RMRAR 1601_ EKSVK 1606_ SQALR 1611_ DAMAR 1616_ QLSRM 1621_ QQMEL 1626_ ASGAP 1631_ RPRKA 1636_ SSAPS 1641_ QGKER 1646_ RPDSP 1651_ TRPTL 1656_ RGSEE 1661_ PTLKH 1666_ EATSE 1671_ EVLSP 1676_ PSDSG 1681_ GPDGS 1686_ FTSSE 1691_ GSSGK 1696_ SKKRS 1701_ SLFSP 1706_ RRNKK 1711_ EKKSK 1716_ GEGRP 1721_ PEKPS 1726_ SNLLE 1731_ EAAAK 1736_ PKSLW 1741_ KSVFS 1746_ GYKKD 1751_ KKKKA 1756_ DDKSC 1761_ PSTPS 1766_ SGATV 1771_ DSGKH 1776_ RVLPV 1781_ VRAEL 1786_ QLRRQ 1791_ LSFSE 1796_ DSDLS 1801_ SDDVL 1806_ EKSSQ 1811_ KSRRE 1816_ PRTYT 1821_ EEELN 1826_ AKLTR 1831_ RVQKA 1836_ ARRQA 1841_ KQEEL 1846_ KRLHR 1851_ AQIIQ 1856_ RQLQQ 1861_ VEERQ 1866_ RRLEE 1871_ RGVAV 1876_ EKALR 1881_ GEAGM 1886_ GKKDD 1891_ PKLMQ 1896_ EWFKL 1901_ VQEKN 1906_ AMVRY 1911_ ESELM 1916_ IFARE 1921_ LELED 1926_ RQSRL 1931_ QQELR 1936_ ERMAV 1941_ EDHLK 1946_ TEEEL 1951_ SEEKQ 1956_ ILNEM 1961_ LEVVE 1966_ QRDSL 1971_ VALLE 1976_ EQRLR 1981_ EREED 1986_ KDLEA 1991_ AMLSK 1996_GFSLN
1: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission