NACHT, LRR and PYD domains-containing protein 9 (Nucleotide-binding oligomerization domain protein 6) (PYRIN and NACHT-containing protein 12)
1_MAESF 6_ FSDFG 11_ LLWYL 16_ KELRK 21_ EEFWK 26_ FKELL 31_ KQPLE 36_ KFELK 41_ PIPWA 46_ ELKKA 51_ SKEDV 56_ AKLLD 61_ KHYPG 66_ KQAWE 71_ VTLNL 76_ FLQIN 81_ RKDLW 86_ TKAQE 91_ EMRNK 96_ LNPYR 101_ KHMKE 106_ TFQLI 111_ WEKET 116_ CLHVP 121_ EHFYK 126_ ETMKN 131_ EYKEL 136_ NDAYT 141_ AAARR 146_ HTVVL 151_ EGPDG 156_ IGKTT 161_ LLRKV 166_ MLDWA 171_ EGNLW 176_ KDRFT 181_ FVFFL 186_ NVCEM 191_ NGIAE 196_ TSLLE 201_ LLSRD 206_ WPESS 211_ EKIED 216_ IFSQP 221_ ERILF 226_ IMDGF 231_ EQLKF 236_ NLQLK 241_ ADLSD 246_ DWRQR 251_ QPMPI 256_ ILSSL 261_ LQKKM 266_ LPESS 271_ LLIAL 276_ GKLAM 281_ QKHYF 286_ MLRHP 291_ KLIKL 296_ LGFSE 301_ SEKKS 306_ YFSYF 311_ FGEKS 316_ KALKV 321_ FNFVR 326_ DNGPL 331_ FILCH 336_ NPFTC 341_ WLVCT 346_ CVKQR 351_ LERGE 356_ DLEIN 361_ SQNTT 366_ YLYAS 371_ FLTTV 376_ FKAGS 381_ QSFPP 386_ KVNRA 391_ RLKSL 396_ CALAA 401_ EGIWT 406_ YTFVF 411_ SHGDL 416_ RRNGL 421_ SESEG 426_ VMWVG 431_ MRLLQ 436_ RRGDC 441_ FAFMH 446_ LCIQE 451_ FCAAM 456_ FYLLK 461_ RPKDD 466_ PNPAI 471_ GSITQ 476_ LVRAS 481_ VVQPQ 486_ TLLTQ 491_ VGIFM 496_ FGIST 501_ EEIVS 506_ MLETS 511_ FGFPL 516_ SKDLK 521_ QEITQ 526_ CLESL 531_ SQCEA 536_ DREAI 541_ AFQEL 546_ FIGLF 551_ ETQEK 556_ EFVTK 561_ VMNFF 566_ EEVFI 571_ YIGNI 576_ EHLVI 581_ ASFCL 586_ KHCQH 591_ LTTLR 596_ MCVEN 601_ IFPDD 606_ SGCIS 611_ DYNEK 616_ LVYWR 621_ ELCSM 626_ FITNK 631_ NFQIL 636_ DMENT 641_ SLDDP 646_ SLAIL 651_ CKALA 656_ QPVCK 661_ LRKLI 666_ FTSVY 671_ FGHDS 676_ ELFKA 681_ VLHNP 686_ HLKLL 691_ SLYGT 696_ SLSQS 701_ DIRHL 706_ CETLK 711_ HPMCK 716_ IEELI 721_ LGKCD 726_ ISSEV 731_ CEDIA 736_ SVLAC 741_ NSKLK 746_ HLSLV 751_ ENPLR 756_ DEGMT 761_ LLCEA 766_ LKHSH 771_ CALER 776_ LMLMY 781_ CCLTS 786_ VSCDS 791_ ISEVL 796_ LCSKS 801_ LSLLD 806_ LGSNA 811_ LEDNG 816_ VASLC 821_ AALKH 826_ PGCSI 831_ RELWL 836_ MGCFL 841_ TSDSC 846_ KDIAA 851_ VLICN 856_ GKLKT 861_ LKLGH 866_ NEIGD 871_ TGVRQ 876_ LCAAL 881_ QHPHC 886_ KLECL 891_ GLQTC 896_ PITRA 901_ CCDDI 906_ AAALI 911_ ACKTL 916_ RSLNL 921_ DWIAL 926_ DADAV 931_ VVLCE 936_ ALSHP 941_ DCALQ 946_ MLGLH 951_ KSGFD 956_ EETQK 961_ ILMSV 966_ EEKIP 971_ HLTIS 976_ HGPWI 981_ DEEYK 986_IRGVL
1: As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments