NLR family CARD domain-containing protein 3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (NACHT, LRR and CARD domains-containing protein 3) (Nucleotide-binding oligomerization domain protein 3)
1_MRKQE 6_ VRTGR 11_ EAGQG 16_ HGTGS 21_ PAEQV 26_ KALMD 31_ LLAGK 36_ GSQGS 41_ QAPQA 46_ LDRTP 51_ DAPLG 56_ PCSND 61_ SRIQR 66_ HRKAL 71_ LSKVG 76_ GGPEL 81_ GGPWH 86_ RLASL 91_ LLVEG 96_ LTDLQ 101_ LREHD 106_ FTQVE 111_ ATRGG 116_ GHPAR 121_ TVALD 126_ RLFLP 131_ LSRVS 136_ VPPRV 141_ SITIG 146_ VAGMG 151_ KTTLV 156_ RHFVR 161_ LWAHG 166_ QVGKD 171_ FSLVL 176_ PLTFR 181_ DLNTH 186_ EKLCA 191_ DRLIC 196_ SVFPH 201_ VGEPS 206_ LAVAV 211_ PARAL 216_ LILDG 221_ LDECR 226_ TPLDF 231_ SNTVA 236_ CTDPK 241_ KEIPV 246_ DHLIT 251_ NIIRG 256_ NLFPE 261_ VSIWI 266_ TSRPS 271_ ASGQI 276_ PGGLV 281_ DRMTE 286_ IRGFN 291_ EEEIK 296_ VCLEQ 301_ MFPED 306_ QALLG 311_ WMLSQ 316_ VQADR 321_ ALYLM 326_ CTVPA 331_ FCRLT 336_ GMALG 341_ HLWRS 346_ RTGPQ 351_ DAELW 356_ PPRTL 361_ CELYS 366_ WYFRM 371_ ALSGE 376_ GQEKG 381_ KASPR 386_ IEQVA 391_ HGGRK 396_ MVGTL 401_ GRLAF 406_ HGLLK 411_ KKYVF 416_ YEQDM 421_ KAFGV 426_ DLALL 431_ QGAPC 436_ SCFLQ 441_ REETL 446_ ASSVA 451_ YCFTH 456_ LSLQE 461_ FVAAA 466_ YYYGA 471_ SRRAI 476_ FDLFT 481_ ESGVS 486_ WPRLG 491_ FLTHF 496_ RSAAQ 501_ RAMQA 506_ EDGRL 511_ DVFLR 516_ FLSGL 521_ LSPRV 526_ NALLA 531_ GSLLA 536_ QGEHQ 541_ AYRTQ 546_ VAELL 551_ QGCLR 556_ PDAAV 561_ CARAI 566_ NVLHC 571_ LHELQ 576_ HTELA 581_ RSVEE 586_ AMESG 591_ ALARL 596_ TGPAH 601_ RAALA 606_ YLLQV 611_ SDACA 616_ QEANL 621_ SLSLS 626_ QGVLQ 631_ SLLPQ 636_ LLYCR 641_ KLRLD 646_ TNQFQ 651_ DPVME 656_ LLGSV 661_ LSGKD 666_ CRIQK 671_ ISLAE 676_ NQISN 681_ KGAKA 686_ LARSL 691_ LVNRS 696_ LTSLD 701_ LRGNS 706_ IGPQG 711_ AKALA 716_ DALKI 721_ NRTLT 726_ SLSLQ 731_ GNTVR 736_ DDGAR 741_ SMAEA 746_ LASNR 751_ TLSML 756_ HLQKN 761_ SIGPM 766_ GAQRM 771_ ADALK 776_ QNRSL 781_ KELMF 786_ SSNSI 791_ GDGGA 796_ KALAE 801_ ALKVN 806_ QGLES 811_ LDLQS 816_ NSISD 821_ AGVAA 826_ LMGAL 831_ CTNQT 836_ LLSLS 841_ LRENS 846_ ISPEG 851_ AQAIA 856_ HALCA 861_ NSTLK 866_ NLDLT 871_ ANLLH 876_ DQGAR 881_ AIAVA 886_ VRENR 891_ TLTSL 896_ HLQWN 901_ FIQAG 906_ AAQAL 911_ GQALQ 916_ LNRSL 921_ TSLDL 926_ QENAI 931_ GDDGA 936_ CAVAR 941_ ALKVN 946_ TALTA 951_ LYLQV 956_ ASIGA 961_ SGAQV 966_ LGEAL 971_ AVNRT 976_ LEILD 981_ LRGNA 986_ IGVAG 991_ AKALA 996_ NALKV 1001_ NSSLR 1006_ RLNLQ 1011_ ENSLG 1016_ MDGAI 1021_ CIATA 1026_ LSGNH 1031_ RLQHI 1036_ NLQGN 1041_ HIGDS 1046_ GARMI 1051_ SEAIK 1056_TNAPT
1: Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106)