Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1)
1_MKTKN 6_ RPPRR 11_ RAPVQ 16_ DTEAT 21_ PGEGT 26_ PDGSL 31_ PNPGP 36_ EPAKG 41_ LRSRP 46_ ARAAA 51_ RAPGE 56_ GRRRR 61_ PGPSG 66_ PGGRR 71_ DSSIQ 76_ RRLES 81_ NERER 86_ QRMHK 91_ LNNAF 96_ QALRE 101_ VIPHV 106_ RADKK 111_ LSKIE 116_ TLTLA 121_ KNYIK 126_ SLTAT 131_ ILTMS 136_ SSRLP 141_ GLEGP 146_ GPKLY 151_ QHYQQ 156_ QQQVA 161_ GGALG 166_ ATEAQ 171_ PQGHL 176_ QRYST 181_QIHSF
1: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity)