Pancreas transcription factor 1 subunit alpha (Class A basic helix-loop-helix protein 29) (bHLHa29) (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)
1_MDAVL 6_ LEHFP 11_ GGLDA 16_ FPSSY 21_ FDEDD 26_ FFTDQ 31_ SSRDP 36_ LEDGD 41_ ELLAD 46_ EQAEV 51_ EFLSH 56_ QLHEY 61_ CYRDG 66_ ACLLL 71_ QPAPP 76_ AAPLA 81_ LAPPS 86_ SGGLG 91_ EPDDG 96_ GGGGY 101_ CCETG 106_ APPGG 111_ FPYSP 116_ GSPPS 121_ CLAYP 126_ CAGAA 131_ VLSPG 136_ ARLRG 141_ LSGAA 146_ AAAAR 151_ RRRRV 156_ RSEAE 161_ LQQLR 166_ QAANV 171_ RERRR 176_ MQSIN 181_ DAFEG 186_ LRSHI 191_ PTLPY 196_ EKRLS 201_ KVDTL 206_ RLAIG 211_ YINFL 216_ SELVQ 221_ ADLPL 226_ RGGGA 231_ GGCGG 236_ PGGGG 241_ RLGGD 246_ SPGSQ 251_ AQKVI 256_ ICHRG 261_ TRSPS 266_ PSDPD 271_ YGLPP 276_ LAGHS 281_ LSWTD 286_ EKQLK 291_ EQNII 296_ RTAKV 301_ WTPED 306_ PRKLN 311_ SKSSF 316_ NNIEN 321_EPPFE
1: Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates