Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (Solute carrier family 29 member 4)
1_MGSVG 6_ SQRLE 11_ EPSVA 16_ GTPDP 21_ GVVMS 26_ FTFDS 31_ HQLEE 36_ AAEAA 41_ QGQGL 46_ RARGV 51_ PAFTD 56_ TTLDE 61_ PVPDD 66_ RYHAI 71_ YFAML 76_ LAGVG 81_ FLLPY 86_ NSFIT 91_ DVDYL 96_ HHKYP 101_ GTSIV 106_ FDMSL 111_ TYILV 116_ ALAAV 121_ LLNNV 126_ LVERL 131_ TLHTR 136_ ITAGY 141_ LLALG 146_ PLLFI 151_ SICDV 156_ WLQLF 161_ SRDQA 166_ YAINL 171_ AAVGT 176_ VAFGC 181_ TVQQS 186_ SFYGY 191_ TGMLP 196_ KRYTQ 201_ GVMTG 206_ ESTAG 211_ VMISL 216_ SRILT 221_ KLLLP 226_ DERAS 231_ TLIFF 236_ LVSVA 241_ LELLC 246_ FLLHL 251_ LVRRS 256_ RFVLF 261_ YTTRP 266_ RDSHR 271_ GRPGL 276_ GRGYG 281_ YRVHH 286_ DVVAG 291_ DVHFE 296_ HPAPA 301_ LAPNE 306_ SPKDS 311_ PAHEV 316_ TGSGG 321_ AYMRF 326_ DVPRP 331_ RVQRS 336_ WPTFR 341_ ALLLH 346_ RYVVA 351_ RVIWA 356_ DMLSI 361_ AVTYF 366_ ITLCL 371_ FPGLE 376_ SEIRH 381_ CILGE 386_ WLPIL 391_ IMAVF 396_ NLSDF 401_ VGKIL 406_ AALPV 411_ DWRGT 416_ HLLAC 421_ SCLRV 426_ VFIPL 431_ FILCV 436_ YPSGM 441_ PALRH 446_ PAWPC 451_ IFSLL 456_ MGISN 461_ GYFGS 466_ VPMIL 471_ AAGKV 476_ SPKQR 481_ ELAGN 486_ TMTVS 491_ YMSGL 496_ TLGSA 501_ VAYCT 506_ YSLTR 511_ DAHGS 516_ CLHAS 521_TANGS
1: Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed:17018840, PubMed:17121826, PubMed:20592246, PubMed:20858707, PubMed:22396231, PubMed:31537831). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (PubMed:15448143, PubMed:20592246, PubMed:22396231). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (PubMed:15448143, PubMed:16099839, PubMed:22396231, PubMed:31537831). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718, PubMed:17018840, PubMed:20592246, PubMed:22396231, PubMed:31537831). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:15448143, PubMed:16099839, PubMed:17018840, PubMed:17121826, PubMed:20858707, PubMed:22396231). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (By similarity). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718, PubMed:20592246, PubMed:31537831). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:17018840). Also transports guanidine (PubMed:16099839)