Achaete-scute homolog 5 (ASH-5) (hASH5) (Class A basic helix-loop-helix protein 47) (bHLHa47)
1_MPMGA 6_ AERGA 11_ GPQSS 16_ AAPWA 21_ GSEKA 26_ AKRGP 31_ SKSWY 36_ PRAAA 41_ SDVTC 46_ PTGGD 51_ GADPK 56_ PGPFG 61_ GGLAL 66_ GPAPR 71_ GTMNN 76_ NFCRA 81_ LVDRR 86_ PLGPP 91_ SCMQL 96_ GVMPP 101_ PRQAP 106_ LPPAE 111_ PLGNV 116_ PFLLY 121_ PGPAE 126_ PPYYD 131_ AYAGV 136_ FPYVP 141_ FPGAF 146_ GVYEY 151_ PFEPA 156_ FIQKR 161_ NERER 166_ QRVKC 171_ VNEGY 176_ ARLRG 181_ HLPGA 186_ LAEKR 191_ LSKVE 196_ TLRAA 201_ IRYIK 206_ YLQEL 211_ LSSAP 216_ DGSTP 221_ PASRG 226_ LPGTG 231_ PCPAP 236_ PATPR 241_ PDRPG 246_ DGEAR 251_ APSSL 256_ VPESS 261_ ESSCF 266_ SPSPF 271_LESEE
1: Transcription factor. Probably binds E-box motifs 5'-CANNTG-3' in complex with transcription factor TCF3/E12. Negatively modulates transcription of target genes such as CDH1/E-cadherin, perhaps by recruiting the PRC2 repressive complex to regulatory elements. Regulates ameloblast development and tooth germ growth, perhaps acting by positively modulating migration of inner enamel epithelium (IEE) cells. Plays a role in enamel formation