Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)
1_MSNVN 6_ LSVSD 11_ FWRVM 16_ MRVCW 21_ LVRQD 26_ SRHQR 31_ IRLPH 36_ LEAVV 41_ IGRGP 46_ ETKIT 51_ DKKCS 56_ RQQVQ 61_ LKAEC 66_ NKGYV 71_ KVKQV 76_ GVNPT 81_ SIDSV 86_ VIGKD 91_ QEVKL 96_ QPGQV 101_ LHMVN 106_ ELYPY 111_ IVEFE 116_ EEAKN 121_ PGLET 126_ HRKRK 131_ RSGNS 136_ DSIER 141_ DAAQE 146_ AEAGT 151_ GLEPG 156_ SNSGQ 161_ CSVPL 166_ KKGKD 171_ APIKK 176_ ESLGH 181_ WSQGL 186_ KISMQ 191_ DPKMQ 196_ VYKDE 201_ QVVVI 206_ KDKYP 211_ KARYH 216_ WLVLP 221_ WTSIS 226_ SLKAV 231_ AREHL 236_ ELLKH 241_ MHTVG 246_ EKVIV 251_ DFAGS 256_ SKLRF 261_ RLGYH 266_ AIPSM 271_ SHVHL 276_ HVISQ 281_ DFDSP 286_ CLKNK 291_ KHWNS 296_ FNTEY 301_ FLESQ 306_ AVIEM 311_ VQEAG 316_ RVTVR 321_ DGMPE 326_ LLKLP 331_ LRCHE 336_ CQQLL 341_ PSIPQ 346_ LKEHL 351_RKHWT
1: DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15044383, PubMed:15380105, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)