Histone H2B type W-T (H2B histone family member W testis-specific) (H2B.W histone 1)
1_MLRTE 6_ VPRLP 11_ RSTTA 16_ IVWSC 21_ HLMAT 26_ ASAMA 31_ GPSSE 36_ TTSEE 41_ QLITQ 46_ EPKEA 51_ NSTTS 56_ QKQSK 61_ QRKRG 66_ RHGPR 71_ RCHSN 76_ CRGDS 81_ FATYF 86_ RRVLK 91_ QVHQG 96_ LSLSR 101_ EAVSV 106_ MDSLV 111_ HDILD 116_ RIATE 121_ AGRLA 126_ RSTKR 131_ QTITA 136_ WETRM 141_ AVRLL 146_ LPGQM 151_ GKLAE 156_ SEGTK 161_ AVLRT 166_SLYAI
1: Atypical histone H2B that can form nucleosomes structurally and dynamically indistinguishable from those containing conventional H2B. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (PubMed:15475252, PubMed:16449661). However, unlike conventional H2B, does not recruit chromosome condensation factors and does not participate in the assembly of mitotic chromosomes (PubMed:16449661). May be important for telomere function and play a role in spermatogenesis (PubMed:16449661, PubMed:19583817)