Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)
1_MADPE 6_ VCCFI 11_ TKILC 16_ AHGGR 21_ MALDA 26_ LLQEI 31_ ALSEP 36_ QLCEV 41_ LQVAG 46_ PDRFV 51_ VLETG 56_ GEAGI 61_ TRSVV 66_ ATTRA 71_ RVCRR 76_ KYCQR 81_ PCDNL 86_ HLCKL 91_ NLLGR 96_ CNYSQ 101_ SERNL 106_ CKYSH 111_ EVLSE 116_ ENFKV 121_ LKNHE 126_ LSGLN 131_ KEELA 136_ VLLLQ 141_ SDPFF 146_ MPEIC 151_ KSYKG 156_ EGRQQ 161_ ICNQQ 166_ PPCSR 171_ LHICD 176_ HFTRG 181_ NCRFP 186_ NCLRS 191_ HNLMD 196_ RKVLA 201_ IMREH 206_ GLNPD 211_ VVQNI 216_ QDICN 221_ SKHMQ 226_ KNPPG 231_ PRAPS 236_ SHRRN 241_ MAYRA 246_ RSKSR 251_ DRFFQ 256_ GSQEF 261_ LASAS 266_ ASAER 271_ SCTPS 276_ PDQIS 281_ HRASL 286_ EDAPV 291_ DDLTR 296_ KFTYL 301_ GSQDR 306_ ARPPS 311_ GSSKA 316_ TDLGG 321_ TSQAG 326_ TSQRF 331_ LENGS 336_ QEDLL 341_ HGNPG 346_ STYLA 351_ SNSTS 356_ APNWK 361_ SLTSW 366_ TNDQG 371_ ARRKT 376_ VFSPT 381_ LPAAR 386_ SSLGS 391_ LQTPE 396_ AVTTR 401_ KGTGL 406_ LSSDY 411_ RIING 416_ KSGTQ 421_ DIQPG 426_ PLFNN 431_ NADGV 436_ ATDIT 441_ STRSL 446_ NYKST 451_ SSGHR 456_ EISSP 461_ RIQDA 466_ GPASR 471_ DVQAT 476_ GRIAD 481_ DADPR 486_ VALVN 491_ DSLSD 496_ VTSTT 501_ SSRVD 506_ DHDSE 511_ EICLD 516_ HLCKG 521_ CPLNG 526_ SCSKV 531_ HFHLP 536_ YRWQM 541_ LIGKT 546_ WTDFE 551_ HMETI 556_ EKGYC 561_ NPGIH 566_ LCSVG 571_ SYTIN 576_ FRVMS 581_ CDSFP 586_ IRRLS 591_ TPSSV 596_ TKPAN 601_ SVFTT 606_ KWIWY 611_ WKNES 616_ GTWIQ 621_ YGEEK 626_ DKRKN 631_ SNVDS 636_ SYLES 641_ LYQSC 646_ PRGVV 651_ PFQAG 656_ SRNYE 661_ LSFQG 666_ MIQTN 671_ IASKT 676_ QKDVI 681_ RRPTF 686_ VPQWY 691_ VQQMK 696_ RGPDH 701_ QPAKT 706_ SSVSL 711_ TATFR 716_ PQEDF 721_ CFLSS 726_ KKYKL 731_ SEIHH 736_ LHPEY 741_ VRVSE 746_ HFKAS 751_ MKNFK 756_ IEKIK 761_ KIENS 766_ ELLDK 771_ FTWKK 776_ SQMKE 781_ EGKLL 786_ FYATS 791_ RAYVE 796_ SICSN 801_ NFDSF 806_ LHETH 811_ ENKYG 816_ KGIYF 821_ AKDAI 826_ YSHKN 831_ CPYDA 836_ KNVVM 841_ FVAQV 846_ LVGKF 851_ TEGNI 856_ TYTSP 861_ PPQFD 866_ SCVDT 871_ RSNPS 876_ VFVIF 881_ QKDQV 886_ YPQYV 891_ IEYTE 896_DKACV
1: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs)