Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein) (SEN1 homolog) (Senataxin)
1_MSTCC 6_ WCTPG 11_ GASTI 16_ DFLKR 21_ YASNT 26_ PSGEF 31_ QTADE 36_ DLCYC 41_ LECVA 46_ EYHKA 51_ RDELP 56_ FLHEV 61_ LWELE 66_ TLRLI 71_ NHFEK 76_ SMKAE 81_ IGDDD 86_ ELYIV 91_ DNNGE 96_ MPLFD 101_ ITGQD 106_ FENKL 111_ RVPLL 116_ EILKY 121_ PYLLL 126_ HERVN 131_ ELCVE 136_ ALCRM 141_ EQANC 146_ SFQVF 151_ DKHPG 156_ IYLFL 161_ VHPNE 166_ MVRRW 171_ AILTA 176_ RNLGK 181_ VDRDD 186_ YYDLQ 191_ EVLLC 196_ LFKVI 201_ ELGLL 206_ ESPDI 211_ YTSSV 216_ LEKGK 221_ LILLP 226_ SHMYD 231_ TTNYK 236_ SYWLG 241_ ICMLL 246_ TILEE 251_ QAMDS 256_ LLLGS 261_ DKQND 266_ FMQSI 271_ LHTME 276_ READD 281_ DSVDP 286_ FWPAL 291_ HCFMV 296_ ILDRL 301_ GSKVW 306_ GQLMD 311_ PIVAF 316_ QTIIN 321_ NASYN 326_ REIRH 331_ IRNSS 336_ VRTKL 341_ EPESY 346_ LDDMV 351_ TCSQI 356_ VYNYN 361_ PEKTK 366_ KDSGW 371_ RTAIC 376_ PDYCP 381_ NMYEE 386_ METLA 391_ SVLQS 396_ DIGQD 401_ MRVHN 406_ STFLW 411_ FIPFV 416_ QSLMD 421_ LKDLG 426_ VAYIA 431_ QVVNH 436_ LYSEV 441_ KEVLN 446_ QTDAV 451_ CDKVT 456_ EFFLL 461_ ILVSV 466_ IELHR 471_ NKKCL 476_ HLLWV 481_ SSQQW 486_ VEAVV 491_ KCAKL 496_ PTTAF 501_ TRSSE 506_ KSSGN 511_ CSKGT 516_ AMISS 521_ LSLHS 526_ MPSNS 531_ VQLAY 536_ VQLIR 541_ SLLKE 546_ GYQLG 551_ QQSLC 556_ KRFWD 561_ KLNLF 566_ LRGNL 571_ SLGWQ 576_ LTSQE 581_ THELQ 586_ SCLKQ 591_ IIRNI 596_ KFKAP 601_ PCNTF 606_ VDLTS 611_ ACKIS 616_ PASYN 621_ KEESE 626_ QMGKT 631_ SRKDM 636_ HCLEA 641_ SSPTF 646_ SKEPM 651_ KVQDS 656_ VLIKA 661_ DNTIE 666_ GDNNE 671_ QNYIK 676_ DVKLE 681_ DHLLA 686_ GSCLK 691_ QSSKN 696_ IFTER 701_ AEDQI 706_ KISTR 711_ KQKSV 716_ KEISS 721_ YTPKD 726_ CTSRN 731_ GPERG 736_ CDRGI 741_ IVSTR 746_ LLTDS 751_ STDAL 756_ EKVST 761_ SNEDF 766_ SLKDD 771_ ALAKT 776_ SKRKT 781_ KVQKD 786_ EICAK 791_ LSHVI 796_ KKQHR 801_ KSTLV 806_ DNTIN 811_ LDENL 816_ TVSNI 821_ ESFYS 826_ RKDTG 831_ VQKGD 836_ GFIHN 841_ LSLDP 846_ SGVLD 851_ DKNGE 856_ QKSQN 861_ NVLPK 866_ EKQLK 871_ NEELV 876_ IFSFH 881_ ENNCK 886_ IQEFH 891_ VDGKE 896_ LIPFT 901_ EMTNA 906_ SEKKS 911_ SPFKD 916_ LMTVP 921_ ESRDE 926_ EMSNS 931_ TSVIY 936_ SNLTR 941_ EQAPD 946_ ISPKS 951_ DTLTD 956_ SQIDR 961_ DLHKL 966_ SLLAQ 971_ ASVIT 976_ FPSDS 981_ PQNSS 986_ QLQRK 991_ VKEDK 996_ RCFTA 1001_ NQNNV 1006_ GDTSR 1011_ GQVII 1016_ ISDSD 1021_ DDDDE 1026_ RILSL 1031_ EKLTK 1036_ QDKIC 1041_ LEREH 1046_ PEQHV 1051_ STVNS 1056_ KEEKN 1061_ PVKEE 1066_ KTETL 1071_ FQFEE 1076_ SDSQC 1081_ FEFES 1086_ SSEVF 1091_ SVWQD 1096_ HPDDN 1101_ NSVQD 1106_ GEKKC 1111_ LAPIA 1116_ NTTNG 1121_ QGCTD 1126_ YVSEV 1131_ VKKGA 1136_ EGIEE 1141_ HTRPR 1146_ SISVE 1151_ EFCEI 1156_ EVKKP 1161_ KRKRS 1166_ EKPMA 1171_ EDPVR 1176_ PSSSV 1181_ RNEGQ 1186_ SDTNK 1191_ RDLVG 1196_ NDFKS 1201_ IDRRT 1206_ STPNS 1211_ RIQRA 1216_ TTVSQ 1221_ KKSSK 1226_ LCTCT 1231_ EPIRK 1236_ VPVSK 1241_ TPKKT 1246_ HSDAK 1251_ KGQNR 1256_ SSNYL 1261_ SCRTT 1266_ PAIVP 1271_ PKKFR 1276_ QCPEP 1281_ TSTAE 1286_ KLGLK 1291_ KGPRK 1296_ AYELS 1301_ QRSLD 1306_ YVAQL 1311_ RDHGK 1316_ TVGVV 1321_ DTRKK 1326_ TKLIS 1331_ PQNLS 1336_ VRNNK 1341_ KLLTS 1346_ QELQM 1351_ QRQIR 1356_ PKSQK 1361_ NRRRL 1366_ SDCES 1371_ TDVKR 1376_ AGSHT 1381_ AQNSD 1386_ IFVPE 1391_ SDRSD 1396_ YNCTG 1401_ GTEVL 1406_ ANSNR 1411_ KQLIK 1416_ CMPSE 1421_ PETIK 1426_ AKHGS 1431_ PATDD 1436_ ACPLN 1441_ QCDSV 1446_ VLNGT 1451_ VPTNE 1456_ VIVST 1461_ SEDPL 1466_ GGGDP 1471_ TARHI 1476_ EMAAL 1481_ KEGEP 1486_ DSSSD 1491_ AEEDN 1496_ LFLTQ 1501_ NDPED 1506_ MDLCS 1511_ QMEND 1516_ NYKLI 1521_ ELIHG 1526_ KDTVE 1531_ VEEDS 1536_ VSRPQ 1541_ LESLS 1546_ GTKCK 1551_ YKDCL 1556_ ETTKN 1561_ QGEYC 1566_ PKHSE 1571_ VKAAD 1576_ EDVFR 1581_ KPGLP 1586_ PPASK 1591_ PLRPT 1596_ TKIFS 1601_ SKSTS 1606_ RIAGL 1611_ SKSLE 1616_ TSSAL 1621_ SPSLK 1626_ NKSKG 1631_ IQSIL 1636_ KVPQP 1641_ VPLIA 1646_ QKPVG 1651_ EMKNS 1656_ CNVLH 1661_ PQSPN 1666_ NSNRQ 1671_ GCKVP 1676_ FGESK 1681_ YFPSS 1686_ SPVNI 1691_ LLSSQ 1696_ SVSDT 1701_ FVKEV 1706_ LKWKY 1711_ EMFLN 1716_ FGQCG 1721_ PPASL 1726_ CQSIS 1731_ RPVPV 1736_ RFHNY 1741_ GDYFN 1746_ VFFPL 1751_ MVLNT 1756_ FETVA 1761_ QEWLN 1766_ SPNRE 1771_ NFYQL 1776_ QVRKF 1781_ PADYI 1786_ KYWEF 1791_ AVYLE 1796_ ECELA 1801_ KQLYP 1806_ KENDL 1811_ VFLAP 1816_ ERINE 1821_ EKKDT 1826_ ERNDI 1831_ QDLHE 1836_ YHSGY 1841_ VHKFR 1846_ RTSVM 1851_ RNGKT 1856_ ECYLS 1861_ IQTQE 1866_ NFPAN 1871_ LNELV 1876_ NCIVI 1881_ SSLVT 1886_ TQRKL 1891_ KAMSL 1896_ LGSRN 1901_ QLARA 1906_ VLNPN 1911_ PMDFC 1916_ TKDLL 1921_ TTTSE 1926_ RIIAY 1931_ LRDFN 1936_ EDQKK 1941_ AIETA 1946_ YAMVK 1951_ HSPSV 1956_ AKICL 1961_ IHGPP 1966_ GTGKS 1971_ KTIVG 1976_ LLYRL 1981_ LTENQ 1986_ RKGHS 1991_ DENSN 1996_ AKIKQ 2001_ NRVLV 2006_ CAPSN 2011_ AAVDE 2016_ LMKKI 2021_ ILEFK 2026_ EKCKD 2031_ KKNPL 2036_ GNCGD 2041_ INLVR 2046_ LGPEK 2051_ SINSE 2056_ VLKFS 2061_ LDSQV 2066_ NHRMK 2071_ KELPS 2076_ HVQAM 2081_ HKRKE 2086_ FLDYQ 2091_ LDELS 2096_ RQRAL 2101_ CRGGR 2106_ EIQRQ 2111_ ELDEN 2116_ ISKVS 2121_ KERQE 2126_ LASKI 2131_ KEVQG 2136_ RPQKT 2141_ QSIII 2146_ LESHI 2151_ ICCTL 2156_ STSGG 2161_ LLLES 2166_ AFRGQ 2171_ GGVPF 2176_ SCVIV 2181_ DEAGQ 2186_ SCEIE 2191_ TLTPL 2196_ IHRCN 2201_ KLILV 2206_ GDPKQ 2211_ LPPTV 2216_ ISMKA 2221_ QEYGY 2226_ DQSMM 2231_ ARFCR 2236_ LLEEN 2241_ VEHNM 2246_ ISRLP 2251_ ILQLT 2256_ VQYRM 2261_ HPDIC 2266_ LFPSN 2271_ YVYNR 2276_ NLKTN 2281_ RQTEA 2286_ IRCSS 2291_ DWPFQ 2296_ PYLVF 2301_ DVGDG 2306_ SERRD 2311_ NDSYI 2316_ NVQEI 2321_ KLVME 2326_ IIKLI 2331_ KDKRK 2336_ DVSFR 2341_ NIGII 2346_ THYKA 2351_ QKTMI 2356_ QKDLD 2361_ KEFDR 2366_ KGPAE 2371_ VDTVD 2376_ AFQGR 2381_ QKDCV 2386_ IVTCV 2391_ RANSI 2396_ QGSIG 2401_ FLASL 2406_ QRLNV 2411_ TITRA 2416_ KYSLF 2421_ ILGHL 2426_ RTLME 2431_ NQHWN 2436_ QLIQD 2441_ AQKRG 2446_ AIIKT 2451_ CDKNY 2456_ RHDAV 2461_ KILKL 2466_ KPVLQ 2471_ RSLTH 2476_ PPTIA 2481_ PEGSR 2486_ PQGGL 2491_ PSSKL 2496_ DSGFA 2501_ KTSVA 2506_ ASLYH 2511_ TPSDS 2516_ KEITL 2521_ TVTSK 2526_ DPERP 2531_ PVHDQ 2536_ LQDPR 2541_ LLKRM 2546_ GIEVK 2551_ GGIFL 2556_ WDPQP 2561_ SSPQH 2566_ PGATP 2571_ PTGEP 2576_ GFPVV 2581_ HQDLS 2586_ HIQQP 2591_ AAVVA 2596_ ALSSH 2601_ KPPVR 2606_ GEPPA 2611_ ASPEA 2616_ STCQS 2621_ KCDDP 2626_ EEELC 2631_ HRREA 2636_ RAFSE 2641_ GEQEK 2646_ CGSET 2651_ HHTRR 2656_ NSRWD 2661_ KRTLE 2666_ QEDSS 2671_SKKRK
1: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111)