Autophagy-related protein 9A (APG9-like 1) (mATG9)
1_MAQFD 6_ TEYQR 11_ LEASY 16_ SDSPP 21_ GEEDL 26_ LVHVA 31_ EGSKS 36_ PWHHI 41_ ENLDL 46_ FFSRV 51_ YNLHQ 56_ KNGFT 61_ CMLIG 66_ EIFEL 71_ MQFLF 76_ VVAFT 81_ TFLVS 86_ CVDYD 91_ ILFAN 96_ KMVNH 101_ SLHPT 106_ EPVKV 111_ TLPDA 116_ FLPAQ 121_ VCSAR 126_ IQENG 131_ SLITI 136_ LVIAG 141_ VFWIH 146_ RLIKF 151_ IYNIC 156_ CYWEI 161_ HSFYL 166_ HALRI 171_ PMSAL 176_ PYCTW 181_ QEVQA 186_ RIVQT 191_ QKEHQ 196_ ICIHK 201_ RELTE 206_ LDIYH 211_ RILRF 216_ QNYMV 221_ ALVNK 226_ SLLPL 231_ RFRLP 236_ GLGEA 241_ VFFTR 246_ GLKYN 251_ FELIL 256_ FWGPG 261_ SLFLN 266_ EWSLK 271_ AEYKR 276_ GGQRL 281_ ELAQR 286_ LSNRI 291_ LWIGI 296_ ANFLL 301_ CPLIL 306_ IWQIL 311_ YAFFS 316_ YAEVL 321_ KREPG 326_ ALGAR 331_ CWSLY 336_ GRCYL 341_ RHFNE 346_ LEHEL 351_ QSRLN 356_ RGYKP 361_ ASKYM 366_ NCFLS 371_ PLLTL 376_ LAKNG 381_ AFFAG 386_ SILAV 391_ LIALT 396_ IYDED 401_ VLAVE 406_ HVLTT 411_ VTLLG 416_ VTVTV 421_ CRSFI 426_ PDQHM 431_ VFCPE 436_ QLLRV 441_ ILAHI 446_ HYMPD 451_ HWQGN 456_ AHRSQ 461_ TRDEF 466_ AQLFQ 471_ YKAVF 476_ ILEEL 481_ LSPIV 486_ TPLIL 491_ IFCLR 496_ PRALE 501_ IIDFF 506_ RNFTV 511_ EVVGV 516_ GDTCS 521_ FAQMD 526_ VRQHG 531_ HPQWL 536_ SAGQT 541_ EASVY 546_ QQAED 551_ GKTEL 556_ SLMHF 561_ AITNP 566_ GWQPP 571_ RESTA 576_ FLGFL 581_ KEQVQ 586_ RDGAA 591_ ASLAQ 596_ GGLLP 601_ ENALF 606_ TSIQS 611_ LQSES 616_ EPLSL 621_ IANVV 626_ AGSSC 631_ RGPPL 636_ PRDLQ 641_ GSRHR 646_ AEVAS 651_ ALRSF 656_ SPLQP 661_ GQAPT 666_ GRAHS 671_ TMTGS 676_ GVDAR 681_ TASSG 686_ SSVWE 691_ GQLQS 696_ LVLSE 701_ YASTE 706_ MSLHA 711_ LYMHQ 716_ LHKQQ 721_ AQAEP 726_ ERHVW 731_ HRRES 736_ DESGE 741_ SAPDE 746_ GGEGA 751_ RAPQS 756_ IPRSA 761_ SYPCA 766_ APRPG 771_ APETT 776_ ALHGG 781_ FQRRY 786_ GGITD 791_ PGTVP 796_ RVPSH 801_ FSRLP 806_ LGGWA 811_ EDGQS 816_ ASRHP 821_ EPVPE 826_ EGSED 831_ELPPQ
1: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed:27510922, PubMed:29437695, PubMed:32513819, PubMed:32610138, PubMed:33106659, PubMed:33468622, PubMed:33850023). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed:16940348, PubMed:22456507, PubMed:33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed:33106659). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed:30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity)