Integral membrane protein GPR155 (G-protein coupled receptor PGR22)
1_MNSNL 6_ PAENL 11_ TIAVN 16_ MTKTL 21_ PTAVT 26_ HGFNS 31_ TNDPP 36_ SMSIT 41_ RLFPA 46_ LLECF 51_ GIVLC 56_ GYIAG 61_ RANVI 66_ TSTQA 71_ KGLGN 76_ FVSRF 81_ ALPAL 86_ LFKNM 91_ VVLNF 96_ SNVDW 101_ SFLYS 106_ ILIAK 111_ ASVFF 116_ IVCVL 121_ TLLVA 126_ SPDSR 131_ FSKAG 136_ LFPIF 141_ ATQSN 146_ DFALG 151_ YPIVE 156_ ALYQT 161_ TYPEY 166_ LQYIY 171_ LVAPI 176_ SLMML 181_ NPIGF 186_ IFCEI 191_ QKWKD 196_ TQNAS 201_ QNKIK 206_ IVGLG 211_ LLRVL 216_ QNPIV 221_ FMVFI 226_ GIAFN 231_ FILDR 236_ KVPVY 241_ VENFL 246_ DGLGN 251_ SFSGS 256_ ALFYL 261_ GLTMV 266_ GKIKR 271_ LKKSA 276_ FVVLI 281_ LLITA 286_ KLLVL 291_ PLLCR 296_ EMVEL 301_ LDKGD 306_ SVVNH 311_ TSLSN 316_ YAFLY 321_ GVFPV 326_ APGVA 331_ IFATQ 336_ FNMEV 341_ EIITS 346_ GMVIS 351_ TFVSA 356_ PIMYV 361_ SAWLL 366_ TFPTM 371_ DPKPL 376_ AYAIQ 381_ NVSFD 386_ ISIVS 391_ LISLI 396_ WSLAI 401_ LLLSK 406_ KYKQL 411_ PHMLT 416_ TNLLI 421_ AQSIV 426_ CAGMM 431_ IWNFV 436_ KEKNF 441_ VGQIL 446_ VFVLL 451_ YSSLY 456_ STYLW 461_ TGLLA 466_ ISLFL 471_ LKKRE 476_ RVQIP 481_ VGIII 486_ ISGWG 491_ IPALL 496_ VGVLL 501_ ITGKH 506_ NGDSI 511_ DSAFF 516_ YGKEQ 521_ MITTA 526_ VTLFC 531_ SILIA 536_ GISLM 541_ CMNQT 546_ AQAGS 551_ YEGFD 556_ QSQSH 561_ KVVEP 566_ GNTAF 571_ EESPA 576_ PVNEP 581_ ELFTS 586_ SIPET 591_ SCCSC 596_ SMGNG 601_ ELHCP 606_ SIEPI 611_ ANTST 616_ SEPVI 621_ PSFEK 626_ NNHCV 631_ SRCNS 636_ QSCIL 641_ AQEEE 646_ QYLQS 651_ GDQQL 656_ TRHVL 661_ LCLLL 666_ IIGLF 671_ ANLSS 676_ CLWWL 681_ FNQEP 686_ GRLYV 691_ ELQFF 696_ CAVFN 701_ FGQGF 706_ ISFGI 711_ FGLDK 716_ HLIIL 721_ PFKRR 726_ LEFLW 731_ NNKDT 736_ AENRD 741_ SPVSE 746_ EIKMT 751_ CQQFI 756_ HYHRD 761_ LCIRN 766_ IVKER 771_ RCGAK 776_ TSAGT 781_ FCGCD 786_ LVSWL 791_ IEVGL 796_ ASDRG 801_ EAVIY 806_ GDRLV 811_ QGGVI 816_ QHITN 821_ EYEFR 826_ DEYLF 831_ YRFLQ 836_ KSPEQ 841_ SPPAI 846_ NANTL 851_ QQERY 856_ KEIEH 861_SSPPS
1: Cholesterol-binding protein that acts as a regulator of mTORC1 signaling pathway (PubMed:36007018). Acts as a sensor of cholesterol to signal cholesterol sufficiency to mTORC1: in presence of cholesterol, binds cholesterol, leading to disruption of the interaction between the GATOR1 and KICSTOR complexes and promotion of mTORC1 signaling (PubMed:36007018, PubMed:39358511). Upon cholesterol starvation, GPR155/LYCHOS is unable to perturb the association between GATOR1 and KICSTOR, leading to mTORC1 signaling inhibition (PubMed:36007018). Binds indole-3-acetic acid and may play a role in tryptophan metabolism (PubMed:39358511)