VPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein)
1_MAVFP 6_ WHSRN 11_ RNYKA 16_ EFASC 21_ RLEAV 26_ PLEFG 31_ DYHPL 36_ KPITV 41_ TESKT 46_ KKVNR 51_ KGSTS 56_ STSSS 61_ SSSSV 66_ VDPLS 71_ SVLDG 76_ TDPLS 81_ MFAAT 86_ ADPAA 91_ LAAAM 96_ DSSRR 101_ KRDRD 106_ DNSVV 111_ GSDFE 116_ PWTNK 121_ RGEIL 126_ ARYTT 131_ TEKLS 136_ INLFM 141_ GSEKG 146_ KAGTA 151_ TLAMS 156_ EKVRT 161_ RLEEL 166_ DDFEE 171_ GSQKE 176_ LLNLT 181_ QQDYV 186_ NRIEE 191_ LNQSL 196_ KDAWA 201_ SDQKV 206_ KALKI 211_ VIQCS 216_ KLLSD 221_ TSVIQ 226_ FYPSK 231_ FVLIT 236_ DILDT 241_ FGKLV 246_ YERIF 251_ SMCVD 256_ SRSVL 261_ PDHFS 266_ PENAN 271_ DTAKE 276_ TCLNW 281_ FFKIA 286_ SIREL 291_ IPRFY 296_ VEASI 301_ LKCNK 306_ FLSKT 311_ GISEC 316_ LPRLT 321_ CMIRG 326_ IGDPL 331_ VSVYA 336_ RAYLC 341_ RVGME 346_ VAPHL 351_ KETLN 356_ KNFFD 361_ FLLTF 366_ KQIHG 371_ DTVQN 376_ QLVVQ 381_ GVELP 386_ SYLPL 391_ YPPAM 396_ DWIFQ 401_ CISYH 406_ APEAL 411_ LTEMM 416_ ERCKK 421_ LGNNA 426_ LLLNS 431_ VMSAF 436_ RAEFI 441_ ATRSM 446_ DFIGM 451_ IKECD 456_ ESGFP 461_ KHLLF 466_ RSLGL 471_ NLALA 476_ DPPES 481_ DRLQI 486_ LNEAW 491_ KVITK 496_ LKNPQ 501_ DYINC 506_ AEVWV 511_ EYTCK 516_ HFTKR 521_ EVNTV 526_ LADVI 531_ KHMTP 536_ DRAFE 541_ DSYPQ 546_ LQLII 551_ KKVIA 556_ HFHDF 561_ SVLFS 566_ VEKFL 571_ PFLDM 576_ FQKES 581_ VRVEV 586_ CKCIM 591_ DAFIK 596_ HQQEP 601_ TKDPV 606_ ILNAL 611_ LHVCK 616_ TMHDS 621_ VNALT 626_ LEDEK 631_ RMLSY 636_ LINGF 641_ IKMVS 646_ FGRDF 651_ EQQLS 656_ FYVES 661_ RSMFC 666_ NLEPV 671_ LVQLI 676_ HSVNR 681_ LAMET 686_ RKVMK 691_ GNHSR 696_ KTAAF 701_ VRACV 706_ AYCFI 711_ TIPSL 716_ AGIFT 721_ RLNLY 726_ LHSGQ 731_ VALAN 736_ QCLSQ 741_ ADAFF 746_ KAAIS 751_ LVPEV 756_ PKMIN 761_ IDGKM 766_ RPSES 771_ FLLEF 776_ LCNFF 781_ STLLI 786_ VPDHP 791_ EHGVL 796_ FLVRE 801_ LLNVI 806_ QDYTW 811_ EDNSD 816_ EKIRI 821_ YTCVL 826_ HLLSA 831_ MSQET 836_ YLYHI 841_ DKVDS 846_ NDSLY 851_ GGDSK 856_ FLAEN 861_ NKLCE 866_ TVMAQ 871_ ILEHL 876_ KTLAK 881_ DEALK 886_ RQSSL 891_ GLSFF 896_ NSILA 901_ HGDLR 906_ NNKLN 911_ QLSVN 916_ LWHLA 921_ QRHGC 926_ ADTRT 931_ MVKTL 936_ EYIKK 941_ QSKQP 946_ DMTHL 951_ TELAL 956_RLPLQ
1: Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947)
2: (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface