Solute carrier family 46 member 3
1_MKILF 6_ VEPAI 11_ FLSAF 16_ AMTLT 21_ GPLTT 26_ QYVYR 31_ RIWEE 36_ TGNYT 41_ FSSDS 46_ NISEC 51_ EKNKS 56_ SPIFA 61_ FQEEV 66_ QKKVS 71_ RFNLQ 76_ MDISG 81_ LIPGL 86_ VSTFI 91_ LLSIS 96_ DHYGR 101_ KFPMI 106_ LSSVG 111_ ALATS 116_ VWLCL 121_ LCYFA 126_ FPFQL 131_ LIAST 136_ FIGAF 141_ CGNYT 146_ TFWGA 151_ CFAYI 156_ VDQCK 161_ EHKQK 166_ TIRIA 171_ IIDFL 176_ LGLVT 181_ GLTGL 186_ SSGYF 191_ IRELG 196_ FEWSF 201_ LIIAV 206_ SLAVN 211_ LIYIL 216_ FFLGD 221_ PVKEC 226_ SSQNV 231_ TMSCS 236_ EGFKN 241_ LFYRT 246_ YMLFK 251_ NASGK 256_ RRFLL 261_ CLLLF 266_ TVITY 271_ FFVVI 276_ GIAPI 281_ FILYE 286_ LDSPL 291_ CWNEV 296_ FIGYG 301_ SALGS 306_ ASFLT 311_ SFLGI 316_ WLFSY 321_ CMEDI 326_ HMAFI 331_ GIFTT 336_ MTGMA 341_ MTAFA 346_ STTLM 351_ MFLAR 356_ VPFLF 361_ TIVPF 366_ SVLRS 371_ MLSKV 376_ VRSTE 381_ QGTLF 386_ ACIAF 391_ LETLG 396_ GVTAV 401_ STFNG 406_ IYSAT 411_ VAWYP 416_ GFTFL 421_ LSAGL 426_ LLLPA 431_ ISLCV 436_ VKCTS 441_ WNEGS 446_ YELLI 451_ QEESS 456_EDASD
1: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (PubMed:36741448). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Transports catabolites of non-cleavable antibody-drug conjugates from the lysosome to the cytoplasm (PubMed:26631267, PubMed:30131388, PubMed:36741448). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable)