Protein RD3 (Retinal degeneration protein 3)
1_MSLIS 6_ WLRWN 11_ EAPSR 16_ LSTRS 21_ PAEMV 26_ LETLM 31_ MELTG 36_ QMREA 41_ ERQQR 46_ ERSNA 51_ VRKVC 56_ TGVDY 61_ SWLAS 66_ TPRST 71_ YDLSP 76_ IERLQ 81_ LEDVC 86_ VKIHP 91_ SYCGP 96_ AILRF 101_ RQLLA 106_ EQEPE 111_ VQEVS 116_ QLFRS 121_ VLQEV 126_ LERMK 131_ QEEEA 136_ HKLTR 141_ QWSLR 146_ PRGSL 151_ ATFKT 156_ RARIS 161_ PFASD 166_ IRTIS 171_ EDVER 176_ DTPPP 181_ LRSWS 186_MPEFR
1: Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:21078983, PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291). Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:21928830, PubMed:27471269, PubMed:29515371, PubMed:30559291). Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983). Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP (PubMed:29515371). Plays an important role for the survival of rods and cones in the retina (By similarity)