Piwi-like protein 4
1_MSGRA 6_ RVKAR 11_ GIARS 16_ PSATE 21_ VGRIQ 26_ ASPLP 31_ RSVDL 36_ SNNEA 41_ SSSNG 46_ FLGTS 51_ RISTN 56_ DKYGI 61_ SSGDA 66_ GSTFM 71_ ERGVK 76_ NKQDF 81_ MDLSI 86_ CTREK 91_ LAHVR 96_ NCKTG 101_ SSGIP 106_ VKLVT 111_ NLFNL 116_ DFPQD 121_ WQLYQ 126_ YHVTY 131_ IPDLA 136_ SRRLR 141_ IALLY 146_ SHSEL 151_ SNKAK 156_ AFDGA 161_ ILFLS 166_ QKLEE 171_ KVTEL 176_ SSETQ 181_ RGETI 186_ KMTIT 191_ LKREL 196_ PSSSP 201_ VCIQV 206_ FNIIF 211_ RKILK 216_ KLSMY 221_ QIGRN 226_ FYNPS 231_ EPMEI 236_ PQHKL 241_ SLWPG 246_ FAISV 251_ SYFER 256_ KLLFS 261_ ADVSY 266_ KVLRN 271_ ETVLE 276_ FMTAL 281_ CQRTG 286_ LSCFT 291_ QTCEK 296_ QLIGL 301_ IVLTR 306_ YNNRT 311_ YSIDD 316_ IDWSV 321_ KPTHT 326_ FQKRD 331_ GTEIT 336_ YVDYY 341_ KQQYD 346_ ITVSD 351_ LNQPM 356_ LVSLL 361_ KKKRN 366_ DNSEA 371_ QLAHL 376_ IPELC 381_ FLTGL 386_ TDQAT 391_ SDFQL 396_ MKAVA 401_ EKTRL 406_ SPSGR 411_ QQRLA 416_ RLVDN 421_ IQRNT 426_ NARFE 431_ LETWG 436_ LHFGS 441_ QISLT 446_ GRIVP 451_ SEKIL 456_ MQDHI 461_ CQPVS 466_ AADWS 471_ KDIRT 476_ CKILN 481_ AQSLN 486_ TWLIL 491_ CSDRT 496_ EYVAE 501_ SFLNC 506_ LRRVA 511_ GSMGF 516_ NVDYP 521_ KIIKV 526_ QENPA 531_ AFVRA 536_ IQQYV 541_ DPDVQ 546_ LVMCI 551_ LPSNQ 556_ KTYYD 561_ SIKKY 566_ LSSDC 571_ PVPSQ 576_ CVLAR 581_ TLNKQ 586_ GMMMS 591_ IATKI 596_ AMQMT 601_ CKLGG 606_ ELWAV 611_ EIPLK 616_ SLMVV 621_ GIDVC 626_ KDALS 631_ KDVMV 636_ VGCVA 641_ SVNPR 646_ ITRWF 651_ SRCIL 656_ QRTMT 661_ DVADC 666_ LKVFM 671_ TGALN 676_ KWYKY 681_ NHDLP 686_ ARIIV 691_ YRAGV 696_ GDGQL 701_ KTLIE 706_ YEVPQ 711_ LLSSV 716_ AESSS 721_ NTSSR 726_ LSVIV 731_ VRKKC 736_ MPRFF 741_ TEMNR 746_ TVQNP 751_ PLGTV 756_ VDSEA 761_ TRNEW 766_ YDFYL 771_ ISQVA 776_ CRGTV 781_ SPTYY 786_ NVIYD 791_ DNGLK 796_ PDHMQ 801_ RLTFK 806_ LCHLY 811_ YNWPG 816_ IVSVP 821_ APCQY 826_ AHKLT 831_ FLVAQ 836_ SIHKE 841_ PSLEL 846_ANHLF
1: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins (By similarity). The PIWIL4-piRNA pathway acts in the nucleus and mediates silencing of active transposons: engages with nascent transposable element transcripts and governs the piRNA-directed DNA methylation and subsequent repression of transposons (By similarity). In contrast to PIWIL1 and PIWIL2, does not show endonuclease activity (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci (PubMed:17544373). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities (By similarity). Plays a role in pancreatic beta cell function and insulin secretion (By similarity). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (PubMed:28025795). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of cells proliferation in tumors (PubMed:22483988)