Transmembrane channel-like protein 6 (Epidermodysplasia verruciformis protein 1) (Protein LAK-4)
1_MAQPL 6_ AFILD 11_ VPETP 16_ GDQGQ 21_ GPSPY 26_ DESEV 31_ HDSFQ 36_ QLIQE 41_ QSQCT 46_ AQEGL 51_ ELQQR 56_ EREVT 61_ GSSQQ 66_ TLWRP 71_ EGTQS 76_ TATLR 81_ ILASM 86_ PSRTI 91_ GRSRG 96_ AIISQ 101_ YYNRT 106_ VQLRC 111_ RSSRP 116_ LLGNF 121_ VRSAW 126_ PSLRL 131_ YDLEL 136_ DPTAL 141_ EEEEK 146_ QSLLV 151_ KELQS 156_ LAVAQ 161_ RDHML 166_ RGMPL 171_ SLAEK 176_ RSLRE 181_ KSRTP 186_ RGKWR 191_ GQPGS 196_ GGVCS 201_ CCGRL 206_ RYACV 211_ LALHS 216_ LGLAL 221_ LSALQ 226_ ALMPW 231_ RYALK 236_ RIGGQ 241_ FGSSV 246_ LSYFL 251_ FLKTL 256_ LAFNA 261_ LLLLL 266_ LVAFI 271_ MGPQV 276_ AFPPA 281_ LPGPA 286_ PVCTG 291_ LELLT 296_ GAGCF 301_ THTVM 306_ YYGHY 311_ SNATL 316_ NQPCG 321_ SPLDG 326_ SQCTP 331_ RVGGL 336_ PYNMP 341_ LAYLS 346_ TVGVS 351_ FFITC 356_ ITLVY 361_ SMAHS 366_ FGESY 371_ RVGST 376_ SGIHA 381_ ITVFC 386_ SWDYK 391_ VTQKR 396_ ASRLQ 401_ QDNIR 406_ TRLKE 411_ LLAEW 416_ QLRHS 421_ PRSVC 426_ GRLRQ 431_ AAVLG 436_ LVWLL 441_ CLGTA 446_ LGCAV 451_ AVHVF 456_ SEFMI 461_ QSPEA 466_ AGQEA 471_ VLLVL 476_ PLVVG 481_ LLNLG 486_ APYLC 491_ RVLAA 496_ LEPHD 501_ SPVLE 506_ VYVAI 511_ CRNLI 516_ LKLAI 521_ LGTLC 526_ YHWLG 531_ RRVGV 536_ LQGQC 541_ WEDFV 546_ GQELY 551_ RFLVM 556_ DFVLM 561_ LLDTL 566_ FGELV 571_ WRIIS 576_ EKKLK 581_ RRRKP 586_ EFDIA 591_ RNVLE 596_ LIYGQ 601_ TLTWL 606_ GVLFS 611_ PLLPA 616_ VQIIK 621_ LLLVF 626_ YVKKT 631_ SLLAN 636_ CQAPR 641_ RPWLA 646_ SHMST 651_ VFLTL 656_ LCFPA 661_ FLGAA 666_ VFLCY 671_ AVWQV 676_ KPSST 681_ CGPFR 686_ TLDTM 691_ YEAGR 696_ VWVRH 701_ LEAAG 706_ PRVSW 711_ LPWVH 716_ RYLME 721_ NTFFV 726_ FLVSA 731_ LLLAV 736_ IYLNI 741_ QVVRG 746_ QRKVI 751_ CLLKE 756_ QISNE 761_ GEDKI 766_ FLINK 771_ LHSIY 776_ ERKER 781_ EERSR 786_ VGTTE 791_ EAAAP 796_PALLT
1: Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:18158319, PubMed:30068544, PubMed:32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:30068544, PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed:18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed:18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity)